G6PT-H6PDH-11βHSD1 triad in the liver and its implication in the pathomechanism of the metabolic syndrome.

World Journal of Hepatology
Ibolya CzegleGabor Banhegyi

Abstract

The metabolic syndrome, one of the most common clinical conditions in recent times, represents a combination of cardiometabolic risk determinants, including central obesity, glucose intolerance, insulin resistance, dyslipidemia, non-alcoholic fatty liver disease and hypertension. Prevalence of the metabolic syndrome is rapidly increasing worldwide as a consequence of common overnutrition and consequent obesity. Although a unifying picture of the pathomechanism is still missing, the key role of the pre-receptor glucocorticoid activation has emerged recently. Local glucocorticoid activation is catalyzed by a triad composed of glucose-6-phosphate-transporter, hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum. The elements of this system can be found in various cell types, including adipocytes and hepatocytes. While the contribution of glucocorticoid activation in adipose tissue to the pathomechanism of the metabolic syndrome has been well established, the relative importance of the hepatic process is less understood. This review summarizes the available data on the role of the hepatic triad and its role in the metabolic syndrome, by confronting experimental findings with clin...Continue Reading

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Citations

Jun 19, 2013·The Journal of Nutritional Biochemistry·Ana VasiljevićGordana Matić
Feb 16, 2016·FEBS Letters·Veronika ZámbóÉva Kereszturi
Sep 3, 2014·Molecular and Cellular Endocrinology·Marina NikolićDanijela Vojnović Milutinović
Apr 4, 2015·Metabolism: Clinical and Experimental·Emanuel PassosJosé Magalhães
Dec 6, 2017·International Journal of Molecular Sciences·Hee Young KangEui-Bae Jeung
Nov 2, 2013·World Journal of Hepatology·Veronika ZámbóMiklós Csala
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paola MarcolongoFederica Pessina
Mar 30, 2021·Metabolism Open·Abdullateef Isiaka AlagbonsiSusan Kebu

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