G9a Is SETting the Stage for Colorectal Oncogenesis.

Genes
Christopher J Bergin, Yannick D Benoit

Abstract

Recently, Kato et al. reported recurrent activating mutations in the SET domain of histone methyltransferase G9a, driving an oncogenic cascade in melanoma. The authors also reported correlations between G9a expression and the regulation of the canonical WNT pathway. Although we could not observe such mutations in human colorectal adenocarcinoma, newly reported findings are of high relevance to colorectal cancer, as WNT target gene signatures were closely associated with G9a expression. Here, we put into perspective such new results on G9a expression in colorectal cancers and the potential relationship with tumor heterogeneity and acquisition of neoplastic stemness.

References

Jan 18, 2006·Nature Cell Biology·Nirit FeldmanYehudit Bergman
Oct 28, 2008·Nature Structural & Molecular Biology·Silvina Epsztejn-LitmanYehudit Bergman
Mar 24, 2011·Proceedings of the National Academy of Sciences of the United States of America·Danny C LeungMatthew C Lorincz
Jul 10, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yannick D BenoitMickie Bhatia
Mar 15, 2016·Nature Reviews. Genetics·Andrew P FeinbergAnita Göndör
Mar 30, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Chi-Wen LuoMei-Ren Pan
Apr 27, 2017·Frontiers in Immunology·Sebastian Scheer, Colby Zaph
Mar 31, 2019·Nature Communications·Evelyne Lima-FernandesCatherine A O'Brien
Apr 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alex MirandaBrad H Nelson
May 13, 2019·Cancer Treatment Reviews·Davide CiardielloFortunato Ciardiello
Jan 5, 2020·Nature Reviews. Gastroenterology & Hepatology·Gerhard JungAjay Goel
Apr 10, 2020·Cancer Discovery·Shinichiro KatoDavid E Fisher
Apr 18, 2020·Signal Transduction and Targeted Therapy·Huijuan WangYinglan Zhao

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft

Software Mentioned

cBioPortal

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.