GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells

Nature Immunology
Hai-Hui XueW J Leonard

Abstract

The interleukin 7 receptor alpha-chain (IL-7Ralpha) is essential for T cell development in both humans and mice and for B cell development in mice. Whereas the transcription factor PU.1 regulates IL-7Ralpha expression in mouse pro-B cells via a GGAA motif, we demonstrate here that GA binding protein (GABP) bound to this site and was essential in the regulation of IL-7Ralpha expression in T cells, where PU.1 is not expressed. Moreover, IL-7Ralpha expression was diminished substantially in thymocytes but was normal on B220(+) fetal liver cells from mouse embryos with diminished expression of GABPalpha. Thus, GABP is essential for the regulation of IL-7Ralpha expression in T cells, and the differential regulation of IL-7Ralpha in distinct lymphoid lineages is achieved at least in part by differential recruitment of factors to the same GGAA motif.

References

Jan 1, 1981·Advances in Immunology·P W Kincade
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·W C SkarnesR S Beddington
Oct 1, 1994·Molecular and Cellular Biology·A L WursterS M Hedrick
Nov 1, 1994·The Journal of Experimental Medicine·J J PeschonB L Davison
Nov 30, 1994·Biochemical and Biophysical Research Communications·F Hemat, K McEntee
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T SudoS Nishikawa
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·K AkashiI L Weissman
Mar 23, 2001·Nature Immunology·K S SchlunsL Lefrançois
Feb 15, 2001·Oncogene·F O BartelD D Spyropoulos
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·J T TanC D Surh
Aug 11, 2001·Neuron·L SchaefferJ P Changeux
Nov 21, 2001·Nature Reviews. Molecular Cell Biology·A D Sharrocks
Mar 1, 2002·Immunity·Rodney P DeKoterHarinder Singh
Mar 22, 2002·Nature Reviews. Immunology·W J Leonard
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Guangchao SuiYang Shi
May 16, 2002·Blood·Terry J Fry, Crystal L Mackall
Oct 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hai-Hui XueWarren J Leonard
Jun 17, 2003·Nature Immunology·Benedict SeddonRose Zamoyska
Jun 17, 2004·Molecular and Cellular Biology·Sika RistevskiPaul J Hertzog

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Citations

Apr 5, 2011·Cellular and Molecular Life Sciences : CMLS·Fumiaki UchiumiSei-ichi Tanuma
Mar 31, 2012·Cellular and Molecular Life Sciences : CMLS·Onur BoymanJonathan Sprent
Aug 3, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·D R BoothUNKNOWN Southern MS Genetics Consortium
Dec 22, 2007·Nature Reviews. Immunology·Ellen V RothenbergMary A Yui
Jun 23, 2009·Nature Reviews. Immunology·Yrina RochmanWarren J Leonard
Feb 9, 2010·The Journal of Biological Chemistry·Shuyang YuHai-Hui Xue
Jul 17, 2008·The Journal of Biological Chemistry·Xuefang JingHai-Hui Xue
Feb 22, 2007·The Journal of Experimental Medicine·Hans DoomsAbul K Abbas
Oct 25, 2007·International Immunology·Agatha VranjkovicJonathan B Angel
Mar 24, 2009·Nucleic Acids Research·C Benjamin LaiDixie L Mager
Apr 23, 2008·Molecular and Cellular Biology·Hai-Hui XueWarren J Leonard
May 9, 2007·Molecular and Cellular Biology·Alexander JaworskiSteven J Burden
Mar 18, 2005·Annual Review of Immunology·Ellen V Rothenberg, Tom Taghon
Sep 5, 2009·The Journal of Clinical Investigation·Nicolas LeuenbergerWalter Wahli
Jan 12, 2005·Arthritis Research & Therapy·Warren J Leonard
Dec 2, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Fumiaki UchiumiSei-Ichi Tanuma
Apr 30, 2013·Cellular and Molecular Life Sciences : CMLS·Noa TalShai Izraeli
Jan 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Zhong-Fa YangAlan G Rosmarin
Apr 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Dana R MarshallStephen J Turner
Mar 14, 2016·Computational Biology and Chemistry·Haruka Ozaki, Wataru Iwasaki
May 9, 2015·International Journal of Molecular Sciences·Jianbao GaoBo Zhu
May 4, 2012·Seminars in Immunology·Florent Carrette, Charles D Surh
Apr 18, 2008·Cytokine·Danylo SirskyjMarko Kryworuchko
Jul 11, 2006·Immunological Reviews·Andrew M IntlekoferSteven L Reiner
Feb 2, 2006·Immunological Reviews·Elizabeth-Sharon David-FungEllen V Rothenberg
Feb 9, 2006·Current Opinion in Immunology·James Hagman, Kara Lukin
Apr 10, 2012·Insect Biochemistry and Molecular Biology·Hiromitsu TanakaMinoru Yamakawa
Aug 25, 2015·Medicinal Research Reviews·Mian LiuYi Tian
Dec 26, 2006·Journal of Muscle Research and Cell Motility·Carter A Herndon, Larry Fromm

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