PMID: 6828152Feb 24, 1983

GABA acts directly on cells of pituitary pars intermedia to alter hormone output

Nature
S A TomikoW W Douglas

Abstract

Recent immunohistochemical evidence from the rat, indicating that gamma-aminobutyric acid (GABA)-containing fibres of central nervous origin project to the pars intermedia of the pituitary1,2, prompts inquiry into the function of this innervation. There is electrophysiological evidence that GABA acts directly on melanotrophs isolated from rat, through bicuculline-blockable receptors, to increase Cl- conductance and thereby drive the membrane potential towards the Cl- equilibrium potential in these cells, resulting in depolarization at rest or reduction of the depolarization caused by excess K+ (ref. 3). As voltage-dependent Ca channels can participate in the regulation of secretion in these cells4, we have now examined the effect of GABA on hormone output and find that it first stimulates and then inhibits spontaneous secretion of melanocyte-stimulating hormone (MSH) and inhibits K+-evoked secretion. Moreover, our pharmacological evidence suggests that similar receptors are involved in the secretory and the electrophysiological responses. A function of the GABAergic innervation may therefore be to regulate hormone output by acting directly on the melanotrophs, and this regulation may be affected by the changes in electrical pro...Continue Reading

References

Nov 1, 1973·The Journal of Endocrinology·A Howe
Nov 1, 1973·The Journal of Cell Biology·C R Hopkins, M G Farquhar
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·W H OertelI J Kopin
Dec 1, 1980·The Journal of Physiology·W W Douglas, P S Taraskevich

Citations

Mar 1, 1988·Cell and Tissue Research·N BäckT Laatikainen
Jul 1, 1992·Pflügers Archiv : European journal of physiology·R Schneggenburger, A Konnerth
Mar 1, 1992·Pflügers Archiv : European journal of physiology·R Schneggenburger, J López-Barneo
Aug 1, 1987·Pflügers Archiv : European journal of physiology·O TalebA Feltz
Jul 20, 1984·European Journal of Pharmacology·C Brown, I L Martin
Jul 1, 1986·Neuroscience Research·Y Yoneda, K Ogita
Jan 1, 1992·Brain Research. Molecular Brain Research·E LouisetL Cazin
Nov 1, 1995·Brain Research. Molecular Brain Research·T ShidaM Tohyama
Jan 1, 1984·Neurochemistry International·Y Yondea, K Kuriyama
Jan 1, 1987·Neurochemistry International·H NakamutaY Yoneda
May 7, 1990·Molecular and Cellular Endocrinology·C HindelangM E Stoeckel
Nov 1, 1986·Brain Research Bulletin·B M Verburg-Van KemenadeA G Driessen
Apr 1, 1992·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K A Gary, B M Chronwall
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·L S Quackenbush, M Fingerman
Feb 26, 1997·European Journal of Pharmacology·I ShibuyaW W Douglas
Oct 14, 2003·Experimental Neurology·Zhilin Song, Glenn I Hatton
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·N C BirnbergE Herbert
Dec 1, 1991·Clinical Endocrinology·J Lado AbealJ Cabezas-Cerrato
May 31, 1993·Annals of the New York Academy of Sciences·Marie-Christine TononHubert Vaudry
May 31, 1993·Annals of the New York Academy of Sciences·S JegouHubert Vaudry
May 31, 1993·Annals of the New York Academy of Sciences·E LouisetL Cazin
Jun 18, 1998·Annals of the New York Academy of Sciences·Laurence DesruesHubert Vaudry
Jun 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·M LamaczHubert Vaudry
Nov 20, 2015·Pigment Cell & Melanoma Research·Gabriel E BertolesiSarah McFarlane
Sep 24, 1986·Brain Research·Y Yoneda, K Ogita
Feb 12, 1986·Brain Research·R A Anderson, R Mitchell
Feb 18, 2016·Journal of Molecular Endocrinology·Niamh X CawleyY Peng Loh
May 31, 1993·Annals of the New York Academy of Sciences·R SchlichterP Feltz

Related Concepts

Chloride Ion Level
Gamma-Aminobutyric Acid, Zinc Salt (2:1)
Melanocyte stimulating hormone
Muscimol
Pituitary Stalk
Potassium
Secretory Rate

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