GABA and nitric oxide in the PVN are involved in arterial pressure control but not in the chemoreflex responses in rats

Autonomic Neuroscience : Basic & Clinical
Josiane C Cruz, Benedito H Machado

Abstract

GABAergic, nitrergic and glutamatergic mechanisms in the PVN on the baseline mean arterial pressure (MAP), heart rate (HR) and on the cardiovascular responses to chemoreflex activation in awake rat were evaluated. Chemoreflex was activated with KCN before and after microinjections into the PVN. Bicuculline into the PVN increased baseline MAP (94+/-3 vs 113+/-5 mmHg) and HR (350+/-9 vs 439+/-18 bpm) but had no effect on the pressor (49+/-5 vs 47+/-6 mmHg) or bradicardic (-213+/-23 vs -256+/-42 bpm) responses (n=7). Kynurenic acid into the PVN (n=6) produced no significant changes in the MAP (98+/-3 vs 100+/-3 mmHg), HR (330+/-5 vs 339+/-12 mmHg) or in the pressor (50+/-4 vs 42+/-4 mmHg) and bradicardic (-252+/-4 vs -285+/-16 bpm) responses to chemoreflex. L-NAME into the PVN (n=8) produced increase in the MAP (94+/-3 vs 113+/-5 mmHg) and HR (350+/-9 vs 439+/-18 bpm) but had no effect on the pressor (52+/-5 vs 47+/-6 mmHg) or bradicardic (-253+/-19 vs -320+/-25 bpm) responses to chemoreflex. We conclude that GABA(A) and nitric oxide in the PVN are involved in the maintenance of the baseline MAP but not in the modulation of the responses to chemoreflex. The results also show that Glutamate receptors in the PVN are not involved in ...Continue Reading

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Citations

Apr 20, 2012·Canadian Journal of Physiology and Pharmacology·Helinton NeckelAlberto A Rasia-Filho
Jul 27, 2010·Autonomic Neuroscience : Basic & Clinical·Josiane C CruzBenedito H Machado
Sep 29, 2009·Autonomic Neuroscience : Basic & Clinical·Josiane de Campos CruzBenedito H Machado
Mar 30, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Lucas A ZenaKênia C Bícego
Sep 7, 2012·Autonomic Neuroscience : Basic & Clinical·Rosiane Batista MastelariMarli Cardoso Martins-Pinge
Aug 24, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John Ciriello, Jason M Moreau

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