PMID: 2124585Oct 1, 1990Paper

GABA antagonism reverses hypoxic respiratory depression in the cat

Journal of Applied Physiology
J E MeltonN H Edelman

Abstract

We assessed the role of gamma-aminobutyric acid (GABA) as a potential causative agent of hypoxic respiratory depression by monitoring the response of the phrenic neurogram to systemic infusion of the GABA antagonist bicuculline (0.01 mg.kg-1.min-1) under control conditions and during isocapnic brain hypoxia produced by CO inhalation in separate groups of anesthetized, glomectomized, vagotomized, paralyzed, and ventilated cats with blood pressure held constant. The maximum effect of bicuculline in subseizure doses in control cats was to increase minute phrenic activity to 151 +/- 14% of preinfusion values. Infusion was continued until seizure activity was seen in the electroencephalogram. A 53% decrease of arterial O2 content resulted in a marked reduction of both peak phrenic amplitude and phrenic firing frequency to 16 and 64% of control values, respectively. Infusion of bicuculline while the level of hypoxia was maintained constant restored both peak phrenic amplitude and phrenic firing frequency to prehypoxic levels. The maximum effect of bicuculline was to increase minute phrenic activity to 123 +/- 13% of the prehypoxic value. These results suggest that although GABA has only a modest role in determining the output of the ...Continue Reading

Citations

Jun 24, 2000·The Japanese Journal of Physiology·F Hayashi, Y Fukuda
Apr 12, 2001·Journal of Applied Physiology·S D LeeG A Farkas
Jul 28, 2012·Journal of Applied Physiology·Jun RenJohn J Greer
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·R S Leung, T D Bradley
May 1, 1995·Journal of Neurosurgery·B J Zink, P J Feustel
Aug 13, 1999·Journal of Applied Physiology·J M Abu-ShaweeshR J Martin
Jun 28, 2002·The Tohoku Journal of Experimental Medicine·Ibrahim GünerTülin Oruç
Sep 6, 2005·Journal of Applied Physiology·Catherine A MayerChristopher G Wilson
Apr 16, 2010·Physiological Reviews·Luc J Teppema, Albert Dahan
Jan 25, 2005·Bulletin of Experimental Biology and Medicine·I A TarakanovN N Tarasova
May 11, 2000·Journal of Neurophysiology·I C SolomonJ A Neubauer
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