PMID: 8587654Aug 1, 1995Paper

GABA concentrations in the striatum following repetitive cerebral ischemia

Neurochemical Research
T MainprizeJ Kalra

Abstract

GABAergic neurons in the striatum are very sensitive to the effects of ischemia. The progressive decline in striatal GABA following transient forebrain ischemia in gerbils may be secondary to either a decreased production or an increase in reuptake mechanisms or both. The current experiment was designed to evaluate release of GABA by stimulation with K+ or inhibition of its uptake with nipecotic acid or their combination (K+ nipecotic) after repetitive forebrain ischemia in gerbils by in-vivo microdialysis on Days 1, 3, 5, and 14 following the insult. Infusion of nipecotic acid or potassium chloride, resulted in a significant increase in extracellular GABA. This response was significantly decreased in the post-ischemic animals. The synergistic effect of increased GABA concentrations by the infusion of nipecotic acid + potassium chloride seem in the controls was not evident in the post-ischemic animals. In conclusion, though there is a reduction in the extracellular GABA concentrations in the first week following an ischemic insult, restorative mechanisms are operative in the second week as seen by the increasing GABA concentrations.

References

Jan 1, 1990·Annual Review of Neuroscience·D W Choi, S M Rothman
Jul 1, 1989·Brain Research. Brain Research Reviews·R R Matsumoto
Dec 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J FolbergrováB K Siesjö
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Citations

May 23, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·A MendelowitschL N Sekhar
Sep 11, 2012·American Journal of Therapeutics·Saleem K Al-NuaimiGlen B Baker

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