PMID: 9537798Apr 16, 1998Paper

GABA-gated Cl- channels in the rat retina

Progress in Retinal and Eye Research
A Feigenspan, J Bormann

Abstract

gamma-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the mammalian retina, and its physiological action is well established. GABA receptors have been localized immunocytochemically in the retina of different mammalian species, and all major retinal cell types have been found to express GABAA receptor subunits. Recently, a new type of GABA receptor with pharmacological and electrophysiological properties different from the known GABAA and GABAB receptors, has been described. These GABAC receptors are found predominantly in the vertebrate retina. This review concentrates on the electrophysiological characterization of GABA receptors expressed by amacrine and bipolar cells of the rat retina. We recorded GABA-induced currents from cultured neonatal amacrine and bipolar cells as well as from isolated bipolar cells of adult animals. While amacrine cells contain a homogeneous population of GABAA receptors, bipolar cells exhibit both GABAA and GABAC responses. Although both receptors gate chloride-selective ion channels, their biophysical and pharmacological properties differ markedly. These functional differences and the cellular distribution of GABAA and GABAC receptors suggest that they have different inhibitory ...Continue Reading

References

Nov 15, 1978·The Journal of Comparative Neurology·R E MarcD M Lam
Jan 1, 1975·Journal of Neurochemistry·G A JohnstonB Twitchin
Jun 15, 1992·The Journal of Comparative Neurology·N VardiP Sterling
Jun 1, 1992·Current Opinion in Neurobiology·W Wisden, P H Seeburg
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R Heidelberger, G Matthews
Aug 1, 1991·British Journal of Pharmacology·T G SmartR L Huganir
Dec 1, 1991·Visual Neuroscience·R G Pourcho, M T Owczarzak
Feb 1, 1990·The Journal of Physiology·S SuzukiA Kaneko
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L PolenzaniR Miledi
Jan 1, 1991·Progress in Neurobiology·L Sivilotti, A Nistri
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G R CuttingG R Uhl
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M D BrowningR W Olsen
Apr 1, 1990·British Journal of Pharmacology·T G Smart, A Constanti
Nov 15, 1990·The Journal of Comparative Neurology·U GreferathH Wässle
Jul 22, 1990·The Journal of Comparative Neurology·U Grünert, H Wässle
Jun 1, 1990·Journal of Neurocytology·H KolbL Dekorver
May 1, 1986·British Journal of Pharmacology·A C Dolphin, R H Scott
Mar 1, 1988·Trends in Neurosciences·J Bormann
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G Heuschneider, R D Schwartz
Oct 23, 1989·Neuroscience Letters·N L Harrison, N A Lambert
Oct 1, 1989·Trends in Pharmacological Sciences·N Bowery
Dec 1, 1989·Neuron·M KhrestchatiskyA J Tobin
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J Bormann, D E Clapham
May 19, 1989·European Journal of Pharmacology·L Sivilotti, A Nistri
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I LlanoB H Gähwiler
Jan 1, 1987·Progress in Neurobiology·S C Massey, D A Redburn

❮ Previous
Next ❯

Citations

Jan 7, 2004·Biochemical and Biophysical Research Communications·Yoshiko TakanoMitsuru Nakazawa
Jun 25, 2003·Biochemical and Biophysical Research Communications·Motoya SatoMitsuru Nakazawa
Jan 19, 2000·Trends in Pharmacological Sciences·J Bormann
Oct 16, 1999·Brain Research. Molecular Brain Research·M M DurkinT A Branchek
May 8, 2004·Seizure : the Journal of the British Epilepsy Association·Emma J Roff HiltonTim Betts
Jan 4, 2003·Visual Neuroscience·Sally I FirthDavid W Marshak
May 13, 2004·Visual Neuroscience·Jozsef Vigh, Paul Witkovsky
Dec 8, 2004·Visual Neuroscience·Moritz J Frech, Kurt H Backus
Nov 24, 1999·Clinical and Experimental Pharmacology & Physiology·U Grünert
Oct 3, 2002·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Sarah L Hosking, Emma J Roff Hilton
Dec 17, 1998·Neuroreport·C ZhangR M Duvoisin
Mar 22, 2008·Neurochemical Research·Patricia SalazarIván Velasco
Mar 3, 2010·Experimental Eye Research·Wei ZhengLuo Lu
May 17, 2007·Biology of the Cell·Matthias Kneussel, Sven Loebrich
Oct 31, 2012·Journal of Neurochemistry·Arturo Israel Machuca-ParraAtaúlfo Martínez-Torres
Oct 2, 2012·Journal of Neuroscience Research·Jinnan YangGuo-Yong Wang
Apr 8, 2009·The Journal of Comparative Neurology·Luz M DelgadoOliver Schmachtenberg
Dec 13, 2006·The Journal of Comparative Neurology·Jin-Dong Ding, Richard J Weinberg
Apr 17, 2008·The European Journal of Neuroscience·Qing-Ping WangSerge Picaud
Aug 28, 1999·The Journal of Comparative Neurology·E L Fletcher, H Wässle
Sep 13, 2003·The Journal of Biological Chemistry·Wei ZhengLuo Lu
Jul 9, 2004·Journal of Neurophysiology·Andreas Feigenspan, Reto Weiler
Jul 12, 2013·Journal of Neurophysiology·Stefano Di MarcoSamuel G Solomon
Mar 28, 2002·Physiological Reviews·Thomas J JentschAnselm A Zdebik
Feb 14, 2020·Investigative Ophthalmology & Visual Science·Kore ChanGillian J McLellan
Jun 2, 2021·Cellular and Molecular Life Sciences : CMLS·Erwan SallardPascal Legendre
Apr 26, 2000·Journal of Medicinal Chemistry·M Chebib, G A Johnston

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved