GABA-immunopositive neurons in rat neocortex with contralateral projections to S-I

Brain Research
Y A GoncharR J Weinberg

Abstract

The callosal projection is traditionally believed to be exclusively excitatory in function. A new method combining lectin-conjugated colloidal gold for retrograde tracing with immunofluorescence for GABA was used to investigate this question. The large majority of neurons retrogradely labeled after injections of tracer into contralateral S-I were GABA-negative cells in layers II-VI. However, GABA-positive neurons projecting to contralateral S-I were also seen. The majority of double-labeled cells were only weakly labeled with tracer; they were located both in superficial and deep cortical layers and represented at least 1% of all retrogradely labeled neurons. Neurons double-labeled for both tracer and GABA in upper layers were found mainly within the central patch of callosally projecting neurons, whereas those in deep layers were scattered throughout contralateral cortex.

References

Jun 26, 1992·Brain Research·C M Hughes, A Peters
Jan 1, 1991·Journal of Neural Transplantation & Plasticity·A BraginJ Hámori
Dec 1, 1990·The Journal of Comparative Neurology·A PetersK Josephson
Jun 15, 1988·The Journal of Comparative Neurology·T VoigtM A Stamnes
Jul 1, 1987·The Journal of Comparative Neurology·C Léránth, M Frotscher
Dec 15, 1994·The Journal of Comparative Neurology·F Martínez-GarcíaL Martínez-Millán
Oct 20, 1994·Behavioural Brain Research·F Conti, T Manzoni
May 1, 1993·Neuroscience Research·T Hattori
Jan 15, 1993·The Journal of Comparative Neurology·Z F KisvárdayU T Eysel

❮ Previous
Next ❯

Citations

Dec 13, 2000·Brain Research. Developmental Brain Research·S L Ding, A J Elberger
Jun 1, 1997·The European Journal of Neuroscience·F Kimura, R W Baughman
Aug 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shozo JinnoPeter Somogyi
Aug 15, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark D EyreZoltan Nusser
Mar 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jamie L ReedJon H Kaas
Apr 18, 1997·Brain Research·A PopratiloffR J Weinberg
Dec 1, 2006·Neuroscience Research·Toshio Kosaka, Katsuko Kosaka
Apr 23, 2005·The European Journal of Neuroscience·Ryohei TomiokaNobuaki Tamamaki
Jul 20, 2007·Journal of Anatomy·Juan L Mendizabal-ZubiagaJose L Bueno-Lopez
Oct 11, 2007·The Journal of Comparative Neurology·Ryohei Tomioka, Kathleen S Rockland
Oct 15, 2014·The Journal of Comparative Neurology·Paolo BarbaresiSanto Gratteri
Jun 24, 2004·Brain Research. Brain Research Reviews·Fiorenzo ContiMarcello Melone
May 1, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·James HarrisPaola Arlotta
Oct 18, 2016·Frontiers in Neural Circuits·Iryna Yavorska, Michael Wehr
Nov 17, 2017·Brain Structure & Function·Maximilian SchmidtSacha J van Albada
Jan 1, 2015·World Journal of Radiology·Mara FabriGabriele Polonara
Mar 5, 2020·Journal of Neurophysiology·Boris TouvykineNuma Dancause
Mar 22, 2018·Frontiers in Cellular Neuroscience·Hector ZuritaAlfonso Junior Apicella
Jun 24, 2017·Brain and Behavior·Paolo BarbaresiSalvatore Amoroso
Jun 1, 2011·Sleep and Biological Rhythms·Dmitry GerashchenkoThomas S Kilduff
Feb 9, 2017·Cerebral Cortex·Crystal RockAlfonso Junior Apicella

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.