PMID: 2487633Jan 1, 1989Paper

GABA-immunoreactive synaptic plexus in the nerve fiber layer of primate retina

Visual Neuroscience
M A KoontzM K Ryan

Abstract

Synaptic contacts onto fibers and somata in the nerve fiber layer (NFL) and ganglion cell layer (GCL) of macaque and human retina were demonstrated at the electron microscopical (EM) level. Many presynaptic processes in monkey NFL are gamma aminobutyric acid (GABA) immunoreactive, using anti-GABA antiserum with an EM immunogold procedure. Immunocytochemistry at the light microscopic level revealed that many GABA-reactive cells in the GCL send branching processes into the NFL, forming a sparse synaptic plexus. The presence of long, unbranched GABA-reactive fibers running horizontally in the NFL and entering the optic nerve suggests that some ganglion cells may be GABAergic. GABA-reactive cells contributing to the plexus appear to be a new class of displaced amacrines that arborize in the NFL.

References

Jun 1, 1986·The Journal of Comparative Neurology·T Voigt
Mar 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P Somogyi, A J Hodgson
Jul 1, 1987·Experimental Eye Research·M K Ryan, A E Hendrickson
Jun 1, 1986·Experimental Eye Research·J L MosingerK M Studholme
Jan 1, 1973·Brain, Behavior and Evolution·C R Noback, F Mettler
Nov 15, 1966·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J E Dowling, B B Boycott
Jul 1, 1968·Archives of Ophthalmology·F M Honrubia, J H Elliott
Sep 1, 1982·The Journal of Comparative Neurology·J M FrederickJ G Hollyfield
Jul 1, 1982·Brain Research Bulletin·J Nguyen-LegrosC Alvarez
Jan 1, 1982·Histochemistry·K TornqvistB Ehinger
May 1, 1965·The British Journal of Ophthalmology·J R WOLTER, R R KNOBLICH

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Citations

Oct 29, 1993·Neuroscience Letters·E Van Haesendonck, L Missotten
Mar 28, 2006·Investigative Ophthalmology & Visual Science·Giovanni CasiniNicholas C Brecha
Jul 22, 1990·The Journal of Comparative Neurology·U Grünert, H Wässle
Sep 8, 2006·Peptides·Eduard SchmidJosef Troger
Jul 1, 1997·Visual Neuroscience·P Z Guimarães, J N Hokoç
Sep 1, 1996·Visual Neuroscience·B Ehinger, C L Zucker
May 2, 2003·The Journal of Comparative Neurology·Elizabeth S YamadaDavid W Marshak
Aug 29, 1998·The Journal of Comparative Neurology·D M BersonE V Famiglietti
Sep 14, 2007·The Journal of Comparative Neurology·Luis Pérez De Sevilla MüllerReto Weiler
Oct 22, 1992·The Journal of Comparative Neurology·E Wieniawa-Narkiewicz, A Hughes
Sep 22, 1991·The Journal of Comparative Neurology·S DavangerJ Storm-Mathisen
Jan 5, 2021·Investigative Ophthalmology & Visual Science·Kwame Antwi-BoasiakoNimesh Patel
Aug 8, 1992·The Journal of Comparative Neurology·S C MasseyR E Marc
Jun 12, 1995·The Journal of Comparative Neurology·N CuencaH Kolb
Oct 1, 1990·The Journal of Comparative Neurology·C A Curcio, K A Allen
Jan 15, 1992·The Journal of Comparative Neurology·J Crooks, H Kolb

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