PMID: 7544606May 1, 1995Paper

GABA immunoreactivity in the nucleus isthmo-opticus of the centrifugal visual system in the pigeon: a light and electron microscopic study

Visual Neuroscience
D MiceliM Médina

Abstract

The present study examined GABA immunoreactivity within the retinopetal nucleus isthmo-opticus (NIO) of the pigeon centrifugal visual system (CVS) using light- (immunohistofluorescence, peroxidase anti-peroxidase: PAP) and electron- (postembedding GABA immunogold) microscopic techniques. In some double-labeling experiments, the retrograde transport of the fluorescent dye rhodamine beta-isothiocyanate (RITC) after its intraocular injection was combined with GABA immunohistofluorescence. GABA-immunoreactive (-ir) somata were demonstrated within the neuropilar zone of the NIO adjacent to the centrifugal cell laminae whereas the centrifugal neurons were always immunonegative. A quantitative ultrastructural analysis was performed which distinguished five categories of axon terminal profiles (P1-5) on the basis of various cytological criteria: type of synaptic contact (symmetrical or asymmetrical); shape, size, and density of synaptic vesicles as well as the immunolabeling (positive or negative), size of profile and appearance of hyaloplasm. Numerous GABA-ir afferents to centrifugal neurons via axon terminal types P2a, P2c, and P3 were observed which comprised 47.1% of the total input. Moreover, the data suggest that some of the P2a ...Continue Reading

References

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Citations

Dec 4, 2003·The Journal of Comparative Neurology·Monique MédinaDom Miceli
Apr 29, 2011·Visual Neuroscience·Martin Wilson, Sarah H Lindstrom
Jul 24, 2010·Visual Neuroscience·Sarah H LindstromMartin Wilson
Oct 19, 2000·Neuroscience and Behavioral Physiology·N P VeselkinJ Repérant

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