GABA interacts with photic signaling in the suprachiasmatic nucleus to regulate circadian phase shifts

Neuroscience
E M MintzH E Albers

Abstract

Circadian rhythms of physiology and behavior in mammals are driven by a circadian pacemaker located in the suprachiasmatic nucleus of the hypothalamus. The majority of neurons in the suprachiasmatic nucleus are GABAergic, and activation of GABA receptors in the suprachiasmatic nucleus can induce phase shifts of the circadian pacemaker both in vivo and in vitro. GABA also modulates the phase shifts induced by light in vivo, and photic information is thought to be conveyed to the suprachiasmatic nucleus by glutamate. In the present study, we examined the interactions between GABA receptor agonists, glutamate agonists, and light in hamsters in vivo. The GABA(A) receptor agonist muscimol and the GABA(B) receptor agonist baclofen were microinjected into the suprachiasmatic nucleus at circadian time 13.5 (early subjective night), followed immediately by a microinjection of N-methyl-D-aspartate (NMDA). Both muscimol and baclofen significantly reduced the phase shifting effects of NMDA. Further, coadministration of tetrodotoxin with baclofen did not alter the inhibition of NMDA by baclofen, suggesting a postsynaptic mechanism for the inhibition of NMDA-induced phase shifts by baclofen. Finally, the phase shifting effects of microinject...Continue Reading

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Citations

Sep 22, 2009·Reviews in Endocrine & Metabolic Disorders·Michael C AntleBrooke D Rakai
Jun 4, 2004·Behavioral Neuroscience·Colleen M Novak, H Elliott Albers
Feb 20, 2004·Journal of Neurophysiology·Jason ItriChristopher S Colwell
Jun 21, 2014·BioMed Research International·Javier AlamillaRaúl Aguilar-Roblero
Sep 11, 2009·Alcoholism, Clinical and Experimental Research·Rebecca A Prosser, J David Glass
Mar 13, 2014·Genes, Brain, and Behavior·K V SandhuO Stork
Aug 22, 2009·Brain Research Reviews·Alan M Rosenwasser
May 8, 2016·The Journal of Endocrinology·Jennifer A Evans
Jun 5, 2007·Pharmacology, Biochemistry, and Behavior·Joseph A SeggioAlan M Rosenwasser
Feb 9, 2008·Journal of Biological Rhythms·J Christopher EhlenH Elliott Albers
Jul 6, 2018·Journal of Biological Rhythms·John K McNeillH Elliott Albers
Mar 13, 2020·Physiological Reviews·Jenna R M HarveyAndrea L Meredith
Mar 27, 2003·Neuroreport·Karen L GambleH Elliott Albers
May 16, 2019·International Journal of Molecular Sciences·Sara HegaziHai-Ying Mary Cheng
Dec 6, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C M Novak, H E Albers
Dec 4, 2020·International Journal of Molecular Sciences·Katie AndrewsJinwei Zhang
Nov 13, 2020·Scientific Reports·Kevin M HannayVictoria Booth
Jan 14, 2021·Neuroscience and Biobehavioral Reviews·Pawan Kumar JhaEtienne Challet
Nov 30, 2016·Frontiers in Neuroendocrinology·H Elliott AlbersDaniel L Hummer
Dec 13, 2005·Brain Research Reviews·L P Morin, C N Allen
Sep 15, 2021·Journal of the Royal Society, Interface·Natthapong SueviriyapanMichael A Henson

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