GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults: an MRS-TMS study

Neurobiology of Aging
Lize HermansKoen Cuypers

Abstract

Edited magnetic resonance spectroscopy (MRS) and transcranial magnetic stimulation (TMS) have often been used to study the integrity of the GABAergic neurotransmission system in healthy aging. To investigate whether the measurement outcomes obtained with these 2 techniques are associated with each other in older human adults, gamma-aminobutyric acid (GABA) levels in the left sensorimotor cortex were assessed with edited MRS in 28 older (63-74 years) and 28 young adults (19-34 years). TMS at rest was then used to measure intracortical inhibition (short-interval intracortical inhibition/long-interval intracortical inhibition), intracortical facilitation, interhemispheric inhibition from left to right primary motor cortex (M1) and recruitment curves of left and right M1. Our observations showed that short-interval intracortical inhibition and long-interval intracortical inhibition in the left M1 were reduced in older adults, while GABA levels did not significantly differ between age groups. Furthermore, MRS-assessed GABA within left sensorimotor cortex was not correlated with TMS-assessed cortical excitability or inhibition. These observations suggest that healthy aging gives rise to altered inhibition at the postsynaptic receptor...Continue Reading

Citations

May 4, 2018·Human Brain Mapping·Celine MaesStephan P Swinnen
Feb 13, 2019·Neurorehabilitation and Neural Repair·Ronan A MooneyWinston D Byblow
Mar 19, 2020·Journal of Clinical Medicine·Riccardo BorzuolaAndrea Macaluso
Jun 16, 2018·Aging·Koen CuypersStephan P Swinnen
Aug 17, 2019·Frontiers in Aging Neuroscience·Marit F L RuitenbergRachael D Seidler
Jun 18, 2020·Frontiers in Aging Neuroscience·Diana HarasymAimee J Nelson
Jan 14, 2021·Scientific Reports·Tiffany BellAshley D Harris
Mar 31, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Andrea GuerraAntonio Suppa
Jan 13, 2022·Experimental Brain Research·Takuya MorishitaFriedhelm C Hummel

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