GABA mediates steroid-induced astrocyte differentiation in the neonatal rat hypothalamus

Journal of Neuroendocrinology
Jessica A MongMargaret M McCarthy

Abstract

Our previous work has demonstrated that astrocytes in the developing arcuate nucleus of the rat hypothalamus are sexually dimorphic as a result of differential exposure to oestradiol. Moreover, our experiments in neonatal rats suggest an absence of oestrogen receptors (ER) in arcuate nucleus astrocytes in vivo. This, along with the conspicuous lack of evidence in the literature confirming the presence of ER in arcuate nucleus astrocytes of the neonatal rat brain, led us to question the mechanism by which oestrogen induces changes in arcuate nucleus astrocyte morphology. Based on our previous findings that oestradiol increases gamma-aminobutyric acid (GABA) levels in the neonatal rat arcuate, we hypothesize that GABA is released from neighbouring oestrogen-sensitive neurones and alters arcuate nucleus astrocyte morphology. Here, we report that in vivo reduction of GABA synthesis in the neonatal rat brain by antisense oligodeoxynucleotides to glutamic acid decarboxylase prevented gonadal steroid-induced astrocyte differentiation in males and testosterone-treated females. Conversely, activation of GABAA receptors with the agonist muscimol increased astrocyte differentiation in females in the absence of gonadal steroids. Given that...Continue Reading

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Citations

Dec 14, 2002·Brain Research. Developmental Brain Research·Jessica A Mong, Margaret M McCarthy
Aug 10, 2012·Neuron Glia Biology·Heather S MalloryLynne A Oland
May 27, 2011·Nature Neuroscience·Margaret M McCarthy, Arthur P Arnold
Jan 16, 2008·Physiological Reviews·Margaret M McCarthy
Aug 25, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Margaret M McCarthy
Mar 28, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Luis Miguel Garcia-SeguraLydia L DonCarlos
Jan 22, 2014·Molecular and Cellular Endocrinology·Estefania Acaz-FonsecaLuis M Garcia-Segura
Nov 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jessica A MongDonald W Pfaff
Jan 23, 2016·Frontiers in Neuroendocrinology·Nancy G ForgerAlexandra Castillo-Ruiz
Sep 15, 2012·Frontiers in Neuroendocrinology·Valerie L HedgesPaul G Mermelstein
Feb 8, 2011·Frontiers in Neuroendocrinology·Margaret M McCarthy
Sep 4, 2010·Trends in Endocrinology and Metabolism : TEM·Christopher L WrightMargaret M McCarthy
Oct 13, 2009·Biochimica Et Biophysica Acta·María-Angeles ArevaloLuis M Garcia-Segura
Apr 24, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Jaclyn M Schwarz, Margaret M McCarthy
Apr 29, 2015·Hormones and Behavior·Margaret M McCarthyKatherine E Kight
Mar 3, 2004·Annals of the New York Academy of Sciences·M M McCarthyS K Amateau
Mar 29, 2008·The European Journal of Neuroscience·Maria M HadjimarkouJessica A Mong
Jul 8, 2008·Journal of Neuroendocrinology·M M McCarthyS L Dean
Apr 4, 2008·Journal of Neurochemistry·Jaclyn M Schwarz, Margaret M McCarthy
Dec 16, 2011·Journal of Neurochemistry·Abraham Rosas-ArellanoAtaúlfo Martínez-Torres
May 15, 2012·The Journal of Comparative Neurology·Ryan T JohnsonCynthia L Jordan
Dec 15, 2010·The European Journal of Neuroscience·Iñigo AzcoitiaLuis M Garcia-Segura
Oct 26, 2006·The American Journal of Geriatric Pharmacotherapy·Wendy M Haywood, Elizabeta B Mukaetova-Ladinska
Sep 12, 2006·Pharmacology, Biochemistry, and Behavior·Bernardo Dubrovsky
Nov 29, 2005·Neuroscience·L L DonCarlosL-M Garcia-Segura
Sep 8, 2016·Molecular Neurobiology·Mirjam Sibbe, Akos Kulik
May 28, 2004·Molecular Psychiatry·J A Mong, D W Pfaff
Jul 13, 2002·The Journal of Comparative Neurology·Aline M DavisStuart A Tobet
Aug 15, 2006·Glia·Luis M Garcia-Segura, Roberto C Melcangi
Jul 7, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Margaret M McCarthy
May 15, 2020·The European Journal of Neuroscience·Lisa FelixChristine R Rose
Feb 26, 2014·Reviews in the Neurosciences·Cuifen WangXiaoniu Dai

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