GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats.

Science Translational Medicine
Samantha M FortinMatthew R Hayes

Abstract

The glucagon-like peptide-1 receptor (GLP-1R) agonist liraglutide is approved for the treatment of obesity; however, there is still much to be learned regarding the neuronal sites of action that underlie its suppressive effects on food intake and body weight. Peripherally administered liraglutide in rats acts in part through central GLP-1Rs in both the hypothalamus and the hindbrain. Here, we extend findings supporting a role for hindbrain GLP-1Rs in mediating the anorectic effects of liraglutide in male rats. To dissociate the contribution of GLP-1Rs in the area postrema (AP) and the nucleus tractus solitarius (NTS), we examined the effects of liraglutide in both NTS AAV-shRNA-driven Glp1r knockdown and AP-lesioned animals. Knockdown of NTS GLP-1Rs, but not surgical lesioning of the AP, attenuated the anorectic and body weight-reducing effects of acutely delivered liraglutide. In addition, NTS c-Fos responses were maintained in AP-lesioned animals. Moreover, NTS Glp1r knockdown was sufficient to attenuate the intake- and body weight-reducing effects of chronic daily administered liraglutide over 3 weeks. Development of improved obesity pharmacotherapies requires an understanding of the cellular phenotypes targeted by GLP-1R ag...Continue Reading

References

Jan 1, 1991·The American Journal of Physiology·H R BerthoudT L Powley
Aug 22, 1985·The Journal of Comparative Neurology·R E Shapiro, R R Miselis
Apr 15, 1985·The Journal of Comparative Neurology·R E Shapiro, R R Miselis
Feb 28, 2002·The Journal of Pharmacology and Experimental Therapeutics·TracyAnn PerryNigel H Greig
Apr 5, 2002·Journal of Molecular Neuroscience : MN·Abba J KastinWeihong Pan
Jun 5, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rafael R SchickVolker Schusdziarra
Aug 20, 2003·Nature Medicine·Matthew J DuringColin N Haile
Nov 8, 2003·Cell and Tissue Research·Takayuki SassaShigeyoshi Itohara
Mar 6, 2004·Eating Behaviors·Kevin R FontaineRoss E Andersen
Jun 29, 2004·Cell and Tissue Research·Bruno PeruzzoEsteban Martín Rodríguez
Feb 8, 2006·Annual Review of Physiology·R Alberto TravagliRichard C Rogers
Apr 29, 2006·Journal of Applied Physiology·Leszek KubinDonald R McCrimmon
Feb 27, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·S WanR A Travagli
Feb 1, 2008·The Proceedings of the Nutrition Society·Lorna S Aucott
Jan 17, 2009·Journal of Chemical Neuroanatomy·Nasren Maolood, Björn Meister
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yazhou LiNigel H Greig
Jan 29, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elena-Dana BaraboiDenis Richard
Oct 16, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tanja BabicR Alberto Travagli
Apr 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paula L McCleanChristian Hölscher
Jul 22, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elena-Dana BaraboiDenis Richard
Sep 15, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Katayun Cohen-Kashi-MalinaVivian I Teichberg
Oct 7, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Naomi J McKayDerek Daniels
Oct 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amanda M DossatDiana L Williams
Jan 18, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S ZhaoM R Hayes

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Citations

Jul 30, 2020·Current Opinion in Pharmacology·Liliana Espinoza, Carie R Boychuk
Dec 16, 2020·Endocrine Reviews·Brent A McLeanDaniel J Drucker
Jan 17, 2021·Molecular Metabolism·Ruth HanssenMarc Tittgemeyer
Nov 17, 2020·Brain Research Bulletin·Huinan ZhangXiaoxing Luo
Dec 8, 2020·American Journal of Physiology. Endocrinology and Metabolism·Alexandre Moura-AssisLicio A Velloso
Dec 6, 2020·Neuron·Chuchu ZhangStephen D Liberles
Feb 17, 2021·Nature Metabolism·Daniel I BrierleyStefan Trapp
Nov 1, 2020·Trends in Pharmacological Sciences·Khalil B RamadiGiovanni Traverso
Jun 3, 2020·Advanced Drug Delivery Reviews·Kerstin StemmerTimo D Müller
Mar 21, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eva Guerrero-HreinsPriya Sumithran
May 8, 2021·Molecular Metabolism·Georgina K C DowsettGiles S H Yeo
May 16, 2021·British Journal of Pharmacology·Diana L Williams
Jul 23, 2021·Clinical Obesity·Mila S WellingElisabeth F C van Rossum
Jun 22, 2021·The Journal of Physiology·Orla R M WoodwardJo E Lewis
Oct 10, 2021·Molecular Metabolism·Daniel J Drucker
Sep 15, 2021·British Journal of Pharmacology·Anita KabahiziKevin W Williams

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