GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.

The Journal of Urology
Minoru MiyazatoN Yoshimura

Abstract

We investigated the effects of intrathecal application of gamma-aminobutyric acid A and B receptor agonists on detrusor overactivity in spinal cord injured rats. Adult female Sprague-Dawley rats were used. At 4 weeks after Th9-10 spinal cord transection awake cystometry and recordings of external urethral sphincter electromyogram were performed to examine the effect of intrathecal application of the gamma-aminobutyric acid A and B agonists muscimol and baclofen or the gamma-aminobutyric acid A and B antagonists bicuculline and saclofen (Tocris Cookson, Ellisville, Missouri), respectively, at the level of the L6-S1 spinal cord. The expression of glutamate decarboxylase 67 mRNA in the L6-S1 spinal cord and dorsal root ganglia was also assessed. Muscimol and baclofen produced a dose dependent inhibition of the number (51% to 73% decrease) and amplitude (35% to 93% decrease) of nonvoiding bladder contractions and a decrease in micturition pressure. The effects of muscimol and baclofen were antagonized by bicuculline and saclofen, respectively. Bursting activity of external urethral sphincter electromyogram was inhibited, corresponding to the inhibition of bladder activity by muscimol and baclofen. Glutamate decarboxylase 67 mRNA le...Continue Reading

References

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Feb 10, 2004·The Journal of Urology·Minoru MiyazatoYoshihide Ogawa
Dec 14, 2004·The Journal of Urology·Minoru MiyazatoYoshihide Ogawa
Oct 4, 2005·Progress in Brain Research·William C de Groat, Naoki Yoshimura
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Citations

May 21, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karl B Thor, William C de Groat
May 23, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Minoru MiyazatoNaoki Yoshimura
Jul 9, 2013·Neurourology and Urodynamics·Naoki YoshimuraSatoru Yoshikawa
Feb 5, 2016·International Urology and Nephrology·Masashi HondaAtsushi Takenaka
Jan 24, 2012·The Journal of Urology·Saori NishijimaHideyuki Yamamoto
Oct 20, 2010·The Urologic Clinics of North America·Anne P Cameron
Aug 3, 2010·Lower Urinary Tract Symptoms·Minoru MiyazatoKimio Sugaya
Nov 8, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Naoki YoshimuraYasuhito Funahashi
Jun 11, 2011·Neurourology and Urodynamics·Karl-Erik AnderssonClaudius Füllhase
Dec 22, 2009·Neurourology and Urodynamics·William C de Groat, Naoki Yoshimura
May 21, 2011·Experimental Neurology·William C de Groat, Naoki Yoshimura
Apr 14, 2017·The Journal of Spinal Cord Medicine·Anna Sophia Del FabroGregory Nemunaitis
Mar 1, 2014·Korean journal of urology·Naoki YoshimuraPradeep Tyagi
Dec 16, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas W FullerChangfeng Tai
Jan 7, 2020·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Naoki YoshimuraTakahiro Shimizu

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