GABA receptor modulation of 5-HT neuronal firing: characterization and effect of moderate in vivo variations in glucocorticoid levels

Neurochemistry International
Sarah J JudgeSarah E Gartside

Abstract

Evidence from electrophysiological studies suggests that 5-HT neuronal firing in the dorsal raphe nucleus (DRN) may be regulated by both GABA(A) and GABA(B) receptors. Here, we addressed the question of whether the activity of individual 5-HT neurons is regulated by both GABA(A) and GABA(B) receptors. In addition, we examined the concentration-response relationships of GABA(A) and GABA(B) receptor activation and determined if GABA receptor regulation of 5-HT neuronal firing is altered by moderate alterations in circulating corticosterone. The activity of 5-HT neurons in the DRN of the rat was examined using in vitro extracellular electrophysiology. The firing of all individual neurons tested was inhibited by both the GABA(A) receptor agonist 4,5,6,7-tetrahydroisoxazolo-[5,4-c]-pyridin-3-ol hydrochloride (THIP) (25 microM) and the GABA(B) receptor agonist baclofen (1 microM). Responses to THIP (5, 10, 25 microM) and baclofen (1, 3, 10 microM) were concentration dependent and attenuated by the GABA(A) and GABA(B) receptor antagonists, bicuculline (50 microM) and phaclofen (200 microM), respectively. To examine the effects of corticosterone on the sensitivity of 5-HT neurons to GABA receptor activation, experiments were conducted ...Continue Reading

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Citations

May 15, 2013·Neuropharmacology·Satoshi Ikemoto, Antonello Bonci
Nov 17, 2010·Molecular Psychiatry·B LuscherN Sahir
Sep 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aki TakahashiKlaus A Miczek
Jan 2, 2016·Chemico-biological Interactions·Sarah J JudgeSarah E Gartside
Oct 4, 2015·General and Comparative Endocrinology·Behrouz RahmaniAli Haeri
May 19, 2007·The European Journal of Neuroscience·S E GartsideS J Judge
Apr 1, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Vikas KauraSarah J Judge
Dec 27, 2011·Neuropharmacology·Caroline E McCardle, Sarah E Gartside
Mar 15, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sarah J JudgeSarah E Gartside
Nov 23, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Edward P MaguireDelia Belelli
Mar 3, 2020·The European Journal of Neuroscience·Sarah E GartsideBas M J Olthof
Nov 28, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Darakhshan Jabeen Haleem
Mar 26, 2021·Neuronal Signaling·Aimée Freeburn, Robert Gordon Keith Munn

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