GABA receptors modulate trigeminovascular nociceptive neurotransmission in the trigeminocervical complex

British Journal of Pharmacology
R J StorerPeter J Goadsby

Abstract

1. GABA (gamma-aminobutyric acid) receptors involved in craniovascular nociceptive pathways were characterised by in vivo microiontophoresis of GABA receptor agonists and antagonists onto neurones in the trigeminocervical complex of the cat. 2. Extracellular recordings were made from neurones in the trigeminocervical complex activated by supramaximal electrical stimulation of superior sagittal sinus, which were subsequently stimulated with L-glutamate. 3. Cell firing evoked by microiontophoretic application of L-glutamate (n=30) was reversibly inhibited by GABA in every cell tested (n=19), the GABA(A) agonist muscimol (n=10) in all cells tested, or both where tested, but not by iontophoresis of either sodium or chloride ions at comparable ejection currents. Inhibited cells received wide dynamic range (WDR) or nociceptive specific input from cutaneous receptive fields on the face or forepaws. 4. The inhibition of trigeminal neurones by GABA or muscimol could be antagonized by the GABA(A) antagonist N-methylbicuculline, 1(S),9(R) in all but two cells tested (n=16), but not by the GABA(B) antagonist 2-hydroxysaclofen (n=11). 5. R(-)-baclofen, a GABA(B) agonist, inhibited the firing of three out of seven cells activated by L-glutam...Continue Reading

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Citations

Aug 30, 2003·Current Pain and Headache Reports·Elcio J PiovesanMichael L Oshinsky
Apr 30, 2004·Current Pain and Headache Reports·Marcelo E BigalAlan M Rapoport
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Jul 9, 2004·British Journal of Pharmacology·Robin James StorerPeter J Goadsby
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Jul 29, 2020·Cephalalgia : an International Journal of Headache·Stephen D SilbersteinHans-Christoph Diener

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