PMID: 8939442Oct 1, 1996Paper

GABA transporter heterogeneity: pharmacology and cellular localization

Neurochemistry International
L A Borden

Abstract

gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. GABA is cleared from the synaptic cleft by specific, high-affinity, sodium- and chloride-dependent transporters, which are thought to be located on presynaptic terminals and surrounding glial cells. While early studies suggested a distinction between neuronal and glial GABA transport, molecular cloning has revealed the existence of genes for four distinct GABA transporters (termed GAT-1, GAT-2, GAT-3 and BGT-1), thus revealing a greater heterogeneity than previously suspected. Heterologous expression has allowed a detailed characterization of their pharmacological properties, and has revealed that GAT-1 is the site of action of the anticonvulsant drug, Tiagabine. In-situ hybridization and immunocytochemistry demonstrate that each transporter has a unique regional distribution in the brain; in conjunction with experiments utilizing cell cultures, the neuronal vs glial localization of the various transporters is being elucidated. Future studies will be directed at determining the role of each transporter in the regulation of GABAergic transmission, and in the design of additional subtype-specific inhibitors, which may serve as novel th...Continue Reading

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E Rodriguez Boulan, D D Sabatini
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T StorckW Stoffel
Jan 1, 1992·DNA and Cell Biology·W C ProbstS C Sealfon
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J GuastellaN Davidson
Aug 31, 1992·Neuroscience Letters·H SnowJ P Bennett
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Q R LiuN Nelson
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S UchidaJ S Handler
Jun 29, 1992·FEBS Letters·Q R LiuN Nelson
Apr 1, 1991·Experimental Neurology·E K O'MalleyC F Dreyfus
Feb 1, 1990·Trends in Neurosciences·G P WilkinA J Cholewinski
Apr 24, 1991·European Journal of Pharmacology·E B NielsenC Braestrup
Oct 25, 1991·Science·B J HoffmanM J Brownstein
Sep 14, 1990·Science·J GuastellaB I Kanner
Aug 20, 1990·FEBS Letters·H NelsonN Nelson
Mar 1, 1987·Epilepsy Research·P Krogsgaard-LarsenA Schousboe
May 1, 1985·Journal of Medicinal Chemistry·F E AliG I Moonsammy
Sep 24, 1982·Science·P H YanceyG N Somero
Oct 1, 1993·Trends in Neurosciences·G Levi, M Raiteri
Sep 1, 1993·Journal of Neurochemistry·D R Marriott, G P Wilkin
Oct 14, 1994·European Journal of Pharmacology·L A BordenC Gluchowski

❮ Previous
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Citations

Aug 2, 2003·Annals of Neurology·Edward J NovotnyDouglas L Rothman
Sep 29, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·B NovakH Lübbert
Jul 18, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·R SchultenH Lübbert
Jun 29, 2005·The Journal of Membrane Biology·M H KarakossianS Eskandari
Nov 13, 2007·The Journal of Membrane Biology·Albert L GonzalesSepehr Eskandari
Jun 1, 2005·Journal of Chemical Neuroanatomy·Marcello MeloneFiorenzo Conti
May 18, 2004·Neurochemistry International·Richard PietStéphane H R Oliet
Jun 10, 2004·Neurochemistry International·A SchousboeO M Larsson
May 18, 2004·Neurochemistry International·Flora JowStephen Lin
Jan 3, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Brian S Meldrum, Michael A Rogawski
Mar 20, 2004·Pharmacology & Therapeutics·Janine L Steiger, Shelley J Russek
Aug 14, 2003·Brain Research·Takeshi TakaradaYukio Yoneda
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Victor L Schuster
Feb 15, 2000·Pharmacology, Biochemistry, and Behavior·U SchmittC Hiemke
Jun 5, 2003·Pharmacology & Therapeutics·Jean-Marc Fritschy, Ina Brünig
Apr 16, 2003·Brain Research. Developmental Brain Research·Andrea MinelliFiorenzo Conti
Feb 22, 2001·Trends in Neurosciences·E Cherubini, F Conti
Dec 26, 2001·Brain Research. Molecular Brain Research·M CrispinoA Giuditta
May 14, 2003·Neurochemistry International·J W Phillis, M H O'Regan
Sep 11, 1999·Neurochemistry International·M R Bennett, V J Balcar
Jul 11, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·U SchmittC Hiemke
Aug 11, 1998·Neuroscience Letters·P BarbaresiM Malatesta
Nov 14, 2002·International Journal of Pharmaceutics·Ken-ichi HosoyaTetsuya Terasaki
Dec 18, 2001·Pediatric Neurology·Y Hachiya, S Takashima
Apr 12, 2002·Epilepsy Research·Salvatore StrianoLeonilda Bilo
Nov 30, 2002·Epilepsy Research·Janet L Stringer, Ahmed M Aribi

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