GABA uptake via GABA transporter-1 modulates GABAergic transmission in the immature hippocampus

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Sampsa SipiläKai Kaila

Abstract

GABA uptake limits GABA actions during synaptic responses when the density of active release sites is high or multiple axons are synchronously activated. GABA transporter-1 (GAT-1) is the main neuronal GABA transporter subtype and is already expressed in the early postnatal rat hippocampus. However, previous studies have demonstrated little functional role for the transporter during this developmental period. We used whole-cell voltage-clamp and field-potential recordings in hippocampal slices of neonatal rats (postnatal day 4-5) to study whether GAT-1 plays a role in GABAergic transmission during spontaneous population oscillations, which are seen as "giant depolarizing potentials" (GDPs) in intracellular recordings. We show that the GDP-associated GABAergic current observed in CA3 pyramidal neurons is strongly enhanced by the GAT-1-specific blocker NO-711 (1-[2-[[(diphenylmethylene)imino]oxy]ethyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride). Our results indicate a novel role for GAT-1 in the control of endogenous activity of the immature hippocampus.

Citations

Sep 12, 2013·Molecular Neurobiology·Juu-Chin LuChih-Tien Wang
Apr 29, 2006·The Journal of Physiology·Sampsa T SipiläKai Kaila
Dec 13, 2006·Neuroscience Research·Keiko NagatomoNoriko Tsuru
May 25, 2005·British Journal of Pharmacology·Samuel B KombianKethireddy V V Ananthalakshmi
Feb 15, 2007·The European Journal of Neuroscience·Sampsa T SipiläKai Kaila
Nov 23, 2011·The European Journal of Neuroscience·Jonas-Frederic Sauer, Marlene Bartos
Feb 6, 2007·Archives of Oral Biology·Khashayar NasseryDavid A S Parker
May 15, 2007·Progress in Brain Research·Mark Farrant, Kai Kaila
Feb 25, 2006·The Journal of Comparative Neurology·Catherine Croft SwanwickJaideep Kapur
Feb 3, 2018·Cancer Biology & Therapy·Naibijiang MaolakuerbanAyiding Xireyazidan
Jul 25, 2006·The Journal of Biological Chemistry·Hua-Ping FanGang Pei
Jul 20, 2007·Journal of Neurophysiology·Adriano Augusto CattaniLaurent Aniksztejn
Oct 12, 2007·Physiological Reviews·Yehezkel Ben-AriRustem Khazipov
May 15, 2020·The European Journal of Neuroscience·Lisa FelixChristine R Rose
Dec 26, 2018·Frontiers in Neurology·Xiaona WangYinsen Song

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