PMID: 8592185Nov 1, 1995Paper

GABAA and GABAC receptors on hybrid bass retinal bipolar cells

Journal of Neurophysiology
H Qian, J E Dowling

Abstract

1. gamma-Aminobutyric acid (GABA) responses from solitory hybrid bass retinal bipolar cells were studied with the use of conventional and perforated whole cell patch-clamp recording. 2. GABA elicited a chloride current in bipolar cells that had both transient and sustained components. The transient component was sensitive to bicuculline and resembled GABAA-mediated currents, whereas the more sustained component was resistant to bicuculline and resembled the responses mediated by GABAC receptors. 3. The bicuculline-resistant GABA responses recorded from the bipolar cells could not be modulated by either diazepam or pentobarbital sodium, and they were unaffected by phaclofen and 2-hydroxysaclofen, GABAB receptor antagonists. On the other hand, the bicuculline-resistant GABA responses could be blocked substantially by imidazole-4-acetic acid (I4AA), a competitive antagonist of GABAC receptors. 4. Noise analysis of the GABA-elicited currents suggested a different single channel conductance for GABAA (10.1 pS) and GABAC receptors (3.6 pS). 5. Zinc, a putative modulator of synaptic transmission, strongly inhibited the GABAC responses on bipolar cells, whereas the GABAA responses were not significantly affected by zinc. 6. The proport...Continue Reading

Citations

Nov 19, 1997·Visual Neuroscience·P D Lukasiewicz, R O Wong
Nov 18, 2010·Visual Neuroscience·V P Connaughton
Jul 13, 2011·Experimental Diabetes Research·Haohua Qian, Harris Ripps
Jul 3, 1999·Physiological Reviews·A MeirR Rahamimoff
Nov 19, 1997·Visual Neuroscience·H QianJ E Dowling
Mar 1, 2005·Visual Neuroscience·Matthew J GastingerDavid W Marshak
Jul 7, 2005·Journal of Neurochemistry·Yi Pan, Haohua Qian
Nov 16, 2002·The Journal of Physiology·Daniela Billups, David Attwell
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Sep 18, 2018·Annual Review of Vision Science·John E Dowling
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Oct 29, 2004·Molecular Pharmacology·Haohua QianParham Khalili
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