GABAA-antagonists and baclofen analgesia

General Pharmacology
M R Zarrindast, M Djavdan

Abstract

1. Intraperitoneal (i.p.) injection of different doses of baclofen (5, 7.5 and 10 mg/kg) induced analgesia in tail-flick test. The effect was dose-dependent. 2. The antinociception induced by baclofen (10 mg/kg, i.p.) was decreased in animals pretreated with bicuculline (1.5 mg/kg, i.p., 30 min), but not with naloxone (1.5 mg/kg, i.p., 30 min). 3. In picrotoxin (1 mg/kg, i.p., 15 min) pretreated mice, baclofen (5 mg/kg, i.p.) showed a significant analgesic effect. 4. Morphine (6 mg/kg, s.c.) induced analgesia which was antagonized by naloxone pretreatment (1.5 mg/kg, i.p.), while bicuculline or picrotoxin did not alter the morphine response. 5. These data suggest that a part of analgesic effect of baclofen may be mediated through GABAA receptor sites, and differs from that of morphine.

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Citations

Oct 26, 2000·European Journal of Pharmacology·M ZarrindastM Sahebgharani
Nov 11, 1999·European Journal of Pharmacology·M R Zarrindast, E Mousa-Ahmadi
Mar 19, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M RezayatM Pirali
May 1, 1996·Pharmacology & Toxicology·M R HeidariM R Zarrindast
Jun 24, 2014·Pharmacology, Biochemistry, and Behavior·Parisa Hasanein, Mohsen Parviz
Jan 1, 1997·Pharmacology & Toxicology·M SabetkasaiM R Zarrindast
Jul 25, 2006·The International Journal of Neuroscience·Mousa SahebgharaniM R Zarrindast
May 22, 2020·ACS Chemical Neuroscience·Caitlin N KentCraig W Lindsley
Oct 6, 2021·BMC Urology·Timothy J NessKeith Hildebrand

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