GABAA-benzodiazepine receptor complex ligands and stress-induced hyperthermia in singly housed mice

Pharmacology, Biochemistry, and Behavior
Berend OlivierT J Zethof

Abstract

Stress-induced hyperthermia (SIH) in singly housed mice, in which the rectal temperature of a mouse is measured twice with a 10-min interval, enables to study the effects of a drug on the basal (T1) and on the stress-enhanced temperature (T2), 10 min later, using the rectal procedure as stressor. SIH (T2-T1) reflects a stress-induced phenomenon sensitive to stress- or anxiety-modifying effects of drugs. Several benzodiazepine agonists (diazepam, chlordiazepoxide, oxazepam and alprazolam) dose-dependently antagonized SIH either in NMRI mice from two different breeders or in BALB/c mice. No major differences in the sensitivity for any of the drugs tested were found between strains or between substrains from different breeders. The selective BZ1 receptor agonists alpidem and zolpidem only at relatively high doses antagonized SIH, whereas flumazenil, FG7142, pentylenetetrazol and phenobarbital did not affect SIH. Alcohol antagonized SIH, and the effects of diazepam could be antagonized by flumazenil. The findings that full BZ receptor agonists have anxiolytic-like effects in the singly housed SIH paradigm are comparable to those previously found in the group-housed version. The singly housed SIH is proposed as a simple and reliable...Continue Reading

References

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Citations

Jul 11, 2002·European Journal of Pharmacology·Tommy PattijBerend Olivier
Feb 26, 2003·European Journal of Pharmacology·Berend OlivierLucianne Groenink
Nov 14, 2002·Behavioural Brain Research·J Adriaan Bouwknecht, Richard Paylor
Dec 17, 2009·Physiology & Behavior·Christiaan H VinkersBerend Olivier
Jun 13, 2009·Pharmacology, Biochemistry, and Behavior·Christiaan H VinkersLucianne Groenink
Dec 5, 2006·Behavioural Brain Research·Allan V KalueffPentti Tuohimaa
May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·Takakazu Oka
Jun 25, 2005·Alcoholism, Clinical and Experimental Research·Susan A FarrJohn E Morley
Apr 1, 2008·British Journal of Pharmacology·A RizziG Calo
Jul 28, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jan G VeeningBerend Olivier
Apr 19, 2008·European Journal of Pharmacology·Christiaan H VinkersLucianne Groenink
Mar 31, 2015·Pharmacology, Biochemistry, and Behavior·Trey ThompsonLisa M Tarantino
Apr 28, 2007·European Journal of Pharmacology·Rachel K Conley, Peter H Hutson
Jun 1, 2009·Current Protocols in Pharmacology·Lucianne GroeninkBerend Olivier
Apr 29, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Donatus Wewura AdongoIliya Hosea Azi

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