PMID: 8592636Sep 29, 1995Paper

GABAA receptor-mediated feedback inhibition in pyramidal neurons of cat motor cortex

Neuroscience Letters
W ChenC P Wu

Abstract

Feedback or recurrent inhibition is generally proposed as a basic component of circuit organization in the brain. However, there is little direct evidence for its existence in the cortex, nor for the nature of the neurotransmitters and receptors involved. Here we address this issue by analyzing the potentials following a single action potential in cat neocortical pyramidal neurons. Using 3 M KCl-filled electrodes, we observed a distinct depolarizing potential that was superimposed on the spike after-potentials in seven out of 81 recorded and the resemblance between its falling phase and the passive decay of membrane potential suggested that the depolarizing potential originated from the cell body or proximal dendrites. This potential was blocked by bicuculline methiodide (10 microM), but not by phaclofen (0.2 mM), suggesting that it was a reversed recurrent IPSP mediated by GABAA receptors.

References

Jul 1, 1982·The Journal of Physiology·B E Alger, R A Nicoll
Jan 1, 1959·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C G PHILLIPS
Dec 1, 1961·The Journal of Physiology·J C ECCLESM ITO

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved