GABA(A) receptor modulation of 5-HT neuronal firing in the median raphe nucleus: implications for the action of anxiolytics

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Sarah J JudgeSarah E Gartside

Abstract

5-HT neurones in the median raphe nucleus (MRN) are involved in anxiety and the sleep/wake cycle. Here, using in vitro electrophysiology, we examined if the firing of MRN 5-HT neurones is regulated by GABA(A) receptors. The GABA(A) receptor agonists THIP and muscimol caused concentration dependent inhibition of MRN 5-HT neurones. The GABA(A) receptor antagonist bicuculline blocked the responses to THIP and muscimol. Bicuculline alone increased the basal firing activity. Responses to THIP were enhanced by the Z hypnotic zolpidem at concentrations selective for the alpha(2)/alpha(3) subunits of the GABA(A) receptor (0.2 and 1microM) but not at a concentration selective for the alpha(1) subunit (0.02microM). Consistent with these functional data, 5-HT neurones have been shown to express the alpha(3) (but not alpha(2)) subunit. The anxiolytic effects of GABA(A) receptor modulators are reportedly mediated by alpha(3)-containing receptors. Hence the MRN 5-HT system may be a target for anxiolytic drugs.

References

Aug 11, 1981·Molecular and Cellular Biochemistry·P Krogsgaard-Larsen, E Falch
Nov 23, 2000·British Journal of Pharmacology·F CrestaniU Rudolph
Dec 7, 2002·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Povl Krogsgaard-LarsenTommy Liljefors
Jun 29, 2004·Behavioural Brain Research·Telma G C S AndradeFrederico G Graeff
Jan 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·James K RowlettGerard R Dawson
Jun 10, 2005·Journal of Neurophysiology·Shaomin LiBernat Kocsis
Sep 16, 2005·Journal of Neurophysiology·Fan JiaPeter A Goldstein

❮ Previous
Next ❯

Citations

Jul 13, 2011·Appetite·Samira Schultz MansurMarta Aparecida Paschoalini
Apr 3, 2010·Behavioural Brain Research·Samira Schultz MansurMarta Aparecida Paschoalini
Aug 13, 2014·Journal of Neurochemistry·Cédric B P MartinRaymond Mongeau
Sep 4, 2013·Journal of Psychopharmacology·Telma Gcs AndradeFrederico G Graeff
May 19, 2007·The European Journal of Neuroscience·S E GartsideS J Judge
Jan 2, 2016·Chemico-biological Interactions·Sarah J JudgeSarah E Gartside

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.