GABAA receptors are expressed and facilitate relaxation in airway smooth muscle.

American Journal of Physiology. Lung Cellular and Molecular Physiology
Kentaro MizutaCharles W Emala

Abstract

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system and exerts its actions via both ionotropic (GABA(A)) channels and metabotropic (GABA(B)) receptors. GABA(A) channels are ubiquitously expressed in neuronal tissues, and in mature neurons modulate an inward chloride current resulting in neuronal inhibition due to membrane hyperpolarization. In airway smooth muscle (ASM) cells, membrane hyperpolarization favors smooth muscle relaxation. Although GABA(A) channels and GABA(B) receptors have been functionally identified on peripheral nerves in the lung, GABA(A) channels have never been identified on ASM itself. We detected the mRNA encoding of the GABA(A) alpha(4)-, alpha(5)-, beta(3)-, delta-, gamma(1-3)-, pi-, and theta-subunits in total RNA isolated from native human and guinea pig ASM and from cultured human ASM cells. Selected immunoblots identified the GABA(A) alpha(4)-, alpha(5)-, beta(3)-, and gamma(2)-subunit proteins in native human and guinea pig ASM and cultured human ASM cells. The GABA(A) beta(3)-subunit protein was immunohistochemically localized to ASM in guinea pig tracheal rings. While muscimol, a specific GABA(A) channel agonist, did not affect the magni...Continue Reading

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Citations

Oct 6, 2012·The Journal of Biological Chemistry·Erwin Sigel, Michael E Steinmann
Sep 16, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·George GallosCharles W Emala
Feb 14, 2009·Journal of Applied Physiology·Neil R GleasonCharles W Emala
Dec 15, 2012·American Journal of Respiratory and Critical Care Medicine·Cheng-Hai ZhangRonghua ZhuGe
Jul 2, 2011·American Journal of Respiratory Cell and Molecular Biology·Kentaro MizutaCharles W Emala
Nov 3, 2010·Respiratory Research·Guoqing WangRonald G Crystal
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Jul 13, 2011·Glia·Moonhee LeePatrick L McGeer
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Sep 26, 2015·American Journal of Respiratory Cell and Molecular Biology·Gene T YocumCharles W Emala
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Nov 30, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gene T YocumCharles W Emala
Jan 29, 2019·The Journal of Clinical Endocrinology and Metabolism·Murielle BochudNasser A Dhayat
Nov 7, 2018·American Journal of Respiratory Cell and Molecular Biology·Charles W Emala
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Oct 16, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Y S Prakash
Feb 11, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·George GallosCharles W Emala
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Feb 2, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Peter D YimCharles W Emala
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Oct 22, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Y S Prakash
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