GABA(A) receptors of hippocampal CA1 regions are involved in the acquisition and expression of morphine-induced place preference

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Ameneh RezayofMohammad-Reza Zarrindast

Abstract

In the present study, the effects of bilateral intra-hippocampal CA1 (intra-CA1) injections of GABA(A) receptor agonist and/or antagonist on the acquisition and expression of morphine-induced place preference in male Wistar rats have been investigated. The conditioning treatments with subcutaneous (s.c.) injections of different doses of morphine (0.5-7.5 mg/kg) induced a conditioned place preference (CPP) for the drug-associated place in a dose-dependent manner. Intra-CA1 administration of the GABA(A) receptor agonist, muscimol (0.25, 0.5 and 1 microg/rat) significantly inhibited the morphine (5 mg/kg, s.c.)-induced CPP. Intra-CA1 injections of different doses of the GABA(A) receptor antagonist, bicuculline (0.25, 0.5 and 1 microg/rat), in combination with an ineffective dose of morphine (0.5 mg/kg, s.c.) elicited a significant CPP. However, muscimol or bicuculline by themselves did not elicit any effect on place conditioning. Furthermore, the muscimol-induced inhibition of morphine response was reversed by bicuculline (1 microg/rat, intra-CA1) administration. On the other hand, the bilateral intra-CA1 injections of muscimol (0.25, 0.5 and 1 microg/rat) or bicuculline (0.5, 1 and 2 microg/rat) significantly decreased the expres...Continue Reading

References

May 1, 1992·Trends in Pharmacological Sciences·G F Koob
Jul 1, 1991·Trends in Pharmacological Sciences·I Izquierdo, J H Medina
Jul 9, 1990·Brain Research·J D BrioniJ L McGaugh
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Nov 21, 1980·European Journal of Pharmacology·M K Ticku, R D Huffman
May 1, 1995·Neurobiology of Learning and Memory·J A Salinas, J L McGaugh
Feb 14, 1995·European Journal of Pharmacology·F Rodríguez De FonsecaM Navarro
Jul 14, 1995·European Journal of Pharmacology·T SuzukiM Misawa
Jun 1, 1996·Pharmacology, Biochemistry, and Behavior·T KivastikL Ahtee
Mar 28, 1996·European Journal of Pharmacology·T S ShippenbergA Lefevour
Sep 1, 1997·Pharmacology, Biochemistry, and Behavior·T P PiepponenL Ahtee
Oct 6, 1997·Science·A I Leshner
Oct 6, 1997·Science·E J Nestler, G K Aghajanian
Jan 19, 2000·Trends in Pharmacological Sciences·J Bormann
Feb 23, 2000·Pharmacology, Biochemistry, and Behavior·C Belzung, S Barreau
May 10, 2001·Hippocampus·J Ferbinteanu, R J McDonald
Jun 26, 2001·Science·E J Nestler
Aug 7, 2002·European Journal of Pharmacology·Manizheh KaramiHedayat Sahraei
Sep 10, 2002·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Zheng-Xiong Xi, Elliot A Stein
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·Ameneh RezayofAli-Haeri-Rohani Haeri-Rohani
Mar 30, 2004·Brain Research·Mohammad-Reza ZarrindastMajid Jafari-Sabet

❮ Previous
Next ❯

Citations

Jun 22, 2013·Behavioural Pharmacology·Esmail RiahiAbbas Haghparast
Apr 21, 2010·Life Sciences·Yassaman RassouliMohammad-Reza Zarrindast
Mar 6, 2007·European Journal of Pharmacology·Ameneh RezayofLadan Delphi
Dec 22, 2020·European Journal of Pharmacology·Sakineh AlijanpourMohammad-Reza Zarrindast

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.