GABA(B) modulation of GABA(A) and glycine receptor-mediated synaptic currents in hypoglossal motoneurons

Respiratory Physiology & Neurobiology
Jennifer A O'BrienA J Berger

Abstract

We studied the effects of GABA(B) receptor activation on either glycine or GABA(A) receptor-mediated synaptic transmission to hypoglossal motoneurons (HMs, P8-13) using a rat brainstem slice preparation. Activation of GABA(B) receptors with baclofen, a GABA(B) receptor agonist, inhibited the amplitude of evoked glycine and GABA(A) receptor-mediated inhibitory postsynaptic currents. Additionally, with blockade of postsynaptic GABA(B) receptors baclofen decreased the frequency of both glycine and GABA(A) receptor-mediated spontaneous miniature inhibitory postsynaptic currents (mIPSCs), indicating a presynaptic site of action. Conversely, the GABA(B) receptor antagonist CGP 35348 increased the frequency of glycine receptor-mediated mIPSCs. Application of the GABA transport blocker SKF 89976A decreased the frequency of glycinergic mIPSCs. Lastly, we compared the effects of baclofen on the frequency of glycine and GABA(A) receptor-mediated mIPSC during HM development. At increased postnatal ages (P8-13 versus P1-3) mIPSC frequency was more strongly reduced by baclofen. These results show that presynaptic GABA(B) receptors inhibits glycinergic and GABAergic synaptic transmission to HMs, and the presynaptic sensitivity to baclofen is ...Continue Reading

References

Jan 1, 1972·Pflügers Archiv : European journal of physiology·H AltmannU Sonnhof
Jan 1, 1995·Pharmacology & Therapeutics·D I Kerr, J Ong
Oct 1, 1993·Trends in Neurosciences·K P Scholz
Feb 1, 1993·Neuron·J S IsaacsonR A Nicoll
Sep 1, 1994·Neuroscience·S M Turgeon, R L Albin
Jul 17, 1998·Science·P JonasJ Sandkühler
Oct 15, 1998·Molecular and Cellular Neurosciences·B MalitschekR Kuhn
Mar 17, 1999·The Journal of Comparative Neurology·M Margeta-MitrovicA I Basbaum

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Citations

Dec 1, 2007·Journal of Neuroendocrinology·D Chesnoy-Marchais, A Meillerais
Dec 23, 2006·The Journal of Physiology·Nancy L ChamberlinAtul Malhotra
Nov 26, 2009·The European Journal of Neuroscience·Dominique Chesnoy-Marchais
Aug 27, 2005·The Journal of Physiology·Marat MukhtarovPiotr Bregestovski
May 9, 2014·Journal of Neurophysiology·Jason S Nasse, Joseph B Travers
Dec 14, 2018·Frontiers in Synaptic Neuroscience·Karin R Aubrey, Stéphane Supplisson
Mar 15, 2019·International Journal of Molecular Sciences·Irene Sánchez-RodríguezJuan D Navarro-López
Mar 9, 2011·Respiratory Physiology & Neurobiology·Albert J Berger

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