GABA(B) receptor activation in the suprachiasmatic nucleus of diurnal and nocturnal rodents

Brain Research Bulletin
Colleen M NovakH Elliott Albers

Abstract

Diurnal (day-active) and nocturnal (night-active) animals have very different daily activity patterns. We recently demonstrated that the suprachiasmatic nucleus (SCN) responds to GABAergic stimulation differently in diurnal and nocturnal animals. Specifically, GABAA receptor activation with muscimol during the subjective day causes phase delays in diurnal grass rats while producing phase advances in nocturnal hamsters. The aim of the following experiments was to determine if diurnal and nocturnal animals differ in their response to GABAB receptor activation in the SCN. Baclofen, a GABAB receptor agonist, was microinjected into the SCN region of grass rats or hamsters under free-running conditions and phase alterations were analyzed. Changes in phase were not detected after baclofen treatment during the subjective day in either grass rats or hamsters. During the night, however, GABAB receptor activation significantly decreased the ability of light to induce phase delays in grass rats. Taken together with previous data from our laboratory, these results demonstrate that, in both hamsters and grass rats, GABAB receptor activation in the SCN significantly affects circadian phase during the night, but not during the day.

References

Feb 1, 1989·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·R D SmithF W Turek
Oct 8, 1999·Journal of Biological Rhythms·J A BlanchongL Smale
Dec 6, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C M Novak, H E Albers
Feb 18, 2004·Journal of Biological Rhythms·Uwe Redlin, N Mrosovsky
Jun 4, 2004·Behavioral Neuroscience·Colleen M Novak, H Elliott Albers

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Citations

Sep 22, 2009·Reviews in Endocrine & Metabolic Disorders·Michael C AntleBrooke D Rakai
Feb 27, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J Christopher Ehlen, Ketema N Paul
Jul 6, 2006·The European Journal of Neuroscience·J Christopher EhlenH Elliott Albers
Oct 13, 2006·Epilepsy & Behavior : E&B·Lee S StewartO Carter Snead
Dec 13, 2005·Brain Research Reviews·L P Morin, C N Allen
May 8, 2016·The Journal of Endocrinology·Jennifer A Evans
Feb 22, 2017·The Journal of Physiology·Lydia HannaTimothy M Brown
Mar 13, 2020·Physiological Reviews·Jenna R M HarveyAndrea L Meredith
Nov 30, 2016·Frontiers in Neuroendocrinology·H Elliott AlbersDaniel L Hummer

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