GABA(B) receptor agonist only reduces ethanol drinking in light-drinking mice

Pharmacology, Biochemistry, and Behavior
Gustavo Roberto Villas BoasRoseli Boerngen-Lacerda

Abstract

Baclofen, a GABA(B) agonist, reduces ethanol intake in animals and humans, but the contrary or no effect was also reported. Our previous study demonstrated that mice characterized as "loss of control over ethanol intake" had different Gabbr1 and Gabbr2 transcription levels, which express, respectively, the GABA(B1) and GABA(B2) subunits in brain areas related to addictive behavior. In the present study, we tested baclofen on ethanol intake in mice exposed to the free-choice paradigm. Adult male Swiss mice, individually housed, had free access to three bottles: ethanol (5% and 10%) and water. The protocol had four phases: acquisition (AC, 10 weeks), withdrawal (W, 4 cycles during 2 weeks of 2 day-free-choice and 2 day-only-water), reexposure (RE, 2 weeks), and adulteration of ethanol solutions with quinine (AD, 2 weeks). Mice characterized as "loss of control" (A, n=11, preference for ethanol in AC and maintenance of ethanol intake levels in AD), heavy (H, n=11, preference for ethanol in AC and reduction of ethanol intake levels in AD), and light (L, n=16, preference for water in all phases) drinkers were randomly distributed into two subgroups receiving either intraperitoneal injections of all doses of baclofen (1.25, 2.5, and ...Continue Reading

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Citations

Oct 22, 2013·Pharmacology, Biochemistry, and Behavior·Boris Tabakoff, Paula L Hoffman
Feb 21, 2014·Psychopharmacology·Andrés P VaraniGraciela N Balerio
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Sep 25, 2020·The International Journal of Neuropsychopharmacology·Eleonora GattaGraziano Pinna

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