GABAB receptor-mediated presynaptic inhibition of glutamatergic transmission in the inferior colliculus

Neuroscience Letters
H SunShu Hui Wu

Abstract

Whole-cell patch clamp recordings were made from ICC neurons in brain slices of 9-16 day old rats. Postsynaptic currents were evoked by electrical stimulation of the lemniscal inputs. Excitatory postsynaptic currents (EPSCs) were isolated pharmacologically by blocking GABA(A) and glycine receptors. EPSCs were further dissected into AMPA and NMDA receptor-mediated responses by adding the receptor antagonists, APV and CNQX, respectively. The internal solution in the recording electrodes contained CsF and TEA to block K(+) channels that might be activated by postsynaptic GABA(B) receptors. The modulatory effects of GABA(B) receptors on EPSCs in ICC neurons were examined by bath application of the GABA(B) receptor agonist, baclofen, and the antagonist, CGP 35348. The amplitudes of EPSCs in ICC neurons were reduced to 34.4+/-3.2% of the control by baclofen (5-10 microM). The suppressive effect by baclofen was concentration-dependent. The reduction of the EPSC amplitude was reversed by CGP35348. The ratio of the 2nd to 1st EPSCs evoked by paired-pulse stimulation was significantly increased after application of baclofen. These results suggest that glutamatergic excitation in the ICC can be modulated by presynaptic GABA(B) receptors. ...Continue Reading

References

May 14, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shu Hui WuJack B Kelly
May 28, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shobhana SivaramakrishnanShigeyuki Kuwada
Oct 8, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiao-Bo LiuEdward G Jones
Aug 11, 2005·Hearing Research·Jeffery A Winer

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Citations

Aug 29, 2007·Experimental Brain Research·Takenobu MurakamiKenji Nakashima
Feb 9, 2013·American Journal of Physiology. Cell Physiology·Xin JinChun Jiang
Apr 29, 2015·Frontiers in Cellular Neuroscience·Sriharsha Kantamneni
Nov 17, 2017·Brain Structure & Function·Yaneri A Ayala, Manuel S Malmierca
Nov 21, 2019·Bulletin of Experimental Biology and Medicine·T E Kovaleva, O A Vedyasova
Jul 28, 2020·Journal of Neural Transmission·Raffaele NardoneViviana Versace
Sep 8, 2021·Frontiers in Integrative Neuroscience·Dorit MöhrleSusanne Schmid

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