GABAB receptors and pain.

Neuropharmacology
Marzia Malcangio

Abstract

Over the past three decades the research on GABAB receptor biology and pharmacology in pain processing has been a fascinating experience. Norman Bowery's fundamental discovery of the existence of the GABAB receptor has led the way to the definition of GABAB molecular mechanisms; patterns of receptor expression in the peripheral and central nervous system; GABAB modulatory functions within the pain pathways. We are now harnessing this acquired knowledge to develop innovative approaches to the therapeutic management of chronic pain through allosteric modulation of the GABAB. Norman's legacy would be ultimately fulfilled by the development of novel analgesics that activate the GABAB receptor. This article is part of the "Special Issue Dedicated to Norman G. Bowery".

Citations

Nov 17, 2017·Toxins·James T Daniel, Richard J Clark
Jul 2, 2019·The Korean Journal of Pain·Faraz Mahdian DehkordiMoosa Javdani
Jun 22, 2018·Molecular Brain·Dale B BoscoLong-Jun Wu
Jun 25, 2020·Nature·Makaía M Papasergi-ScottGeorgios Skiniotis
Aug 11, 2020·Drug Metabolism and Personalized Therapy·Mariia A SlepukhinaDmitriy A Sychev
Jul 6, 2020·Journal of Molecular Neuroscience : MN·Mei ZhuZhijie Lu
Aug 9, 2020·Frontiers in Cellular Neuroscience·Marie-Amélie PaponMarc Landry
Jun 30, 2019·International Journal of Molecular Sciences·Seoyon Yang, Min Cheol Chang
Jan 27, 2021·Trends in Pharmacological Sciences·Lars Edvinsson, Kristian Agmund Haanes
Jan 7, 2021·International Journal of Molecular Sciences·Antonella Comitato, Rita Bardoni
Oct 28, 2019·European Journal of Pharmacology·Nobuhito MuraiMitsuyuki Matsumoto
May 30, 2021·Science Advances·Hamidreza ShayeVadim Cherezov
Aug 20, 2021·Physiological Reports·Rodolfo Delgado-LezamaVinicio Granados-Soto

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