GABA(B) receptors couple directly to the transcription factor ATF4

Molecular and Cellular Neurosciences
E VernonJeremy M Henley

Abstract

The inhibitory neurotransmitter gamma-aminobutyric acid (GABA), acts at ionotropic (GABA(A) and GABA(C)) and metabotropic (GABA(B)) receptors. Functional GABA(B) receptors are heterodimers of GABA(B(1)) and GABA(B(2)) subunits. Here we show a robust, direct, and specific interaction between the coiled-coil domain present in the C-terminus of the GABA(B(1)) subunit and the transcription factor ATF4 (also known as CREB2). ATF4 and GABA(B(2)) binding to the GABA(B(1)) subunit were mutually exclusive. In rat hippocampal neurons native GABA(B(1)) showed surprisingly little similarity to GABA(B(2)) in its subcellular distribution. GABA(B(1)) and ATF4, however, were highly colocalized throughout the cell and displayed a punctate distribution within the dendrites. Activation of GABA(B) receptors in hippocampal neurons caused a dramatic translocation of ATF4 out of the nucleus into the cytoplasm. These data suggest a novel neuronal signaling pathway that could regulate the functional expression of GABA(B) receptors and/or modulate gene transcription.

References

Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B A KarpinskiJ M Leiden
Jan 1, 1995·Pharmacology & Therapeutics·D I Kerr, J Ong
Jun 1, 1994·Current Opinion in Neurobiology·A J Silva, K P Giese
Mar 11, 1996·Brain Research·I FerrerA M Planas
Apr 1, 1996·Current Opinion in Neurobiology·J C Yin, T Tully
Jul 4, 1998·Brain Research. Brain Research Reviews·T Abel, E Kandel
Aug 11, 1998·Neuron·A NishimuneJ M Henley
Jan 5, 1999·Science·R KunerH C Kornau
Sep 28, 1999·Trends in Pharmacological Sciences·F H MarshallB Bettler

❮ Previous
Next ❯

Citations

Nov 20, 2004·Nature Reviews. Neuroscience·Graham L CollingridgeYu Tian Wang
Oct 4, 2007·Molecular Psychiatry·J E ChubbJ K Millar
Oct 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kwok-On LaiKelsey C Martin
Nov 17, 2001·The Journal of Biological Chemistry·Béatrice DutheyLaurent Prézeau
Mar 23, 2013·Brain : a Journal of Neurology·Jesús F Torres-PerazaJosé J Lucas
Jan 24, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Xinnong JiangJianfeng Liu
Mar 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·L E BarrettJ H Eberwine
Sep 29, 2011·Experimental Cell Research·Yusuke HiwatashiKen-ichi Yasumoto
Oct 6, 2005·Alcoholism, Clinical and Experimental Research·Douglas B MatthewsRobert W Williams
Jan 24, 2007·Journal of Neurochemistry·Sriharsha KantamneniAtsushi Nishimune
Apr 29, 2006·Pharmacology & Therapeutics·Bernhard Bettler, Jim Yu-Hsiang Tiao
Feb 28, 2014·TheScientificWorldJournal·Quratulane GillaniFurhan Iqbal
Jan 5, 2011·Neuropharmacology·Nicholas J Bradshaw, David J Porteous
Jun 16, 2015·BioMed Research International·Na Wang, Junyu Xu
Sep 24, 2004·Neuropharmacology·Sônia A L CorrêaJeremy M Henley
Jan 7, 2004·The Journal of Biological Chemistry·Benjamin P FairfaxAndrés Couve
Jan 14, 2004·The Journal of Biological Chemistry·Andrés CouveStephen J Moss
Jul 23, 2004·Physiological Reviews·Bernhard BettlerMartin Gassmann
Jan 1, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Mei QuDai Zhang
Dec 14, 2018·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Miho Terunuma
Apr 26, 2005·Addiction Biology·Paula Hoffman, Boris Tabakoff
Aug 26, 2006·Cell and Tissue Research·Hans-Christian Kornau
Aug 2, 2007·Journal of Cellular Biochemistry·René L VidalAndrés Couve
Dec 5, 2008·Journal of Molecular Neuroscience : MN·Maxime RicherTerence E Hébert
Apr 26, 2008·Journal of Receptor and Signal Transduction Research·Benoit BoivinTerence E Hébert
Sep 26, 2015·Pharmacological Reviews·Esa R KorpiGavin S Dawe
Sep 19, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chuan-Ging WuXin Wei Wang
Aug 9, 2020·Frontiers in Cellular Neuroscience·Marie-Amélie PaponMarc Landry
Jun 5, 2003·Pharmacology & Therapeutics·Jean-Philippe PinLaurent Prézeau
Nov 19, 2003·Biochemical and Biophysical Research Communications·J Kirsty MillarDavid J Porteous
Oct 7, 2004·Pharmacology & Therapeutics·Joël BockaertPhilippe Marin
Sep 17, 2005·Brain Research. Molecular Brain Research·Joshua G HunsbergerSamuel S Newton
Apr 16, 2009·Journal of Proteome Research·Berta SunyerGert Lubec

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.