GABAB receptors in reward processes

Advances in Pharmacology
Styliani Vlachou, Athina Markou

Abstract

gamma-aminobutyric acid (GABA) is the predominant inhibitory neurotransmitter in the brain which acts through different receptor subtypes. Metabotropic GABA(B) receptors are widely distributed throughout the brain. Alterations in GABA signaling through pharmacological activation or deactivation of the GABA(B) receptor regulate behavior and brain reward processes. GABA(B) receptor agonists and, most recently, positive modulators have been found to inhibit the reinforcing effects of drugs of abuse, such as cocaine, amphetamine, nicotine, ethanol, and opiates. This converging evidence of the effects of GABA(B) compounds on the reinforcing properties of addictive drugs is based on behavioral studies that used a variety of procedures with relevance to reward processes and drug abuse liability, including intracranial self-stimulation, intravenous self-administration under both fixed- and progressive-ratio schedules of reinforcement, reinstatement, and conditioned place preference. GABA(B) receptor agonists and positive modulators block the reinforcing effects of drugs of abuse in these animal models. However, GABA(B) receptor agonists also have undesirable side-effects. GABA(B) receptor modulators have potential advantages as medicat...Continue Reading

Citations

Nov 4, 2011·Human Genetics·Wen-Yan CuiMing D Li
Dec 31, 2011·Human Genetics·Eric W KleeStephen C Ekker
Sep 29, 2011·The Journal of Pharmacology and Experimental Therapeutics·Julie G HenslerWouter Koek
Feb 10, 2012·The Journal of Pharmacology and Experimental Therapeutics·Wouter KoekKenner C Rice
Jan 1, 2013·The Journal of Pharmacology and Experimental Therapeutics·Wouter KoekKenner C Rice
Sep 5, 2012·Reviews in the Neurosciences·Matthew C HearingKevin Wickman
Mar 25, 2011·Future Medicinal Chemistry·Wolfgang Froestl
Oct 2, 2012·Annual Review of Entomology·Clint J Perry, Andrew B Barron
Nov 12, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·ZhengLin ZhaoRongJie Zhao
Sep 10, 2014·Expert Opinion on Drug Discovery·Tamara J Phillips, Cheryl Reed
May 6, 2016·Frontiers in Psychiatry·Irene LorraiGiancarlo Colombo
Oct 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Olivia F O'LearyJohn F Cryan
Sep 10, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andres OrtFranz X Vollenweider
Jun 19, 2013·European Addiction Research·Roberta AgabioGian Luigi Gessa
Nov 28, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elena Martín-GarcíaVéronique Deroche-Gamonet
Jul 12, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amine Bahi
May 4, 2012·Psychopharmacology·Heidi KemppainenKalervo Kiianmaa
Jan 28, 2014·The European Journal of Neuroscience·Dave J HayesJeffrey W Dalley
Apr 20, 2014·Journal of Clinical Psychopharmacology·Konstantinos MargetisDamianos Sakas
Apr 17, 2014·Psychiatry and Clinical Neurosciences·Chih-Hung KoJu-Yu Yen
Jul 16, 2014·PloS One·Chia-Hsiang ChenDing-Lieh Liao
Jun 29, 2014·Pharmacological Reviews·S Stevens Negus, Laurence L Miller
Sep 26, 2015·Pharmacological Reviews·Esa R KorpiGavin S Dawe
Dec 2, 2011·The Journal of Pharmacology and Experimental Therapeutics·M Paola CastelliFederico Corelli
Jul 15, 2015·Phytotherapy Research : PTR·Muhammad Sona KhanRobert D E Sewell
Jan 16, 2016·CNS Drugs·Ole SchjerningJimmi Nielsen
Apr 19, 2017·Addiction Biology·Andres P VaraniGraciela N Balerio
Sep 18, 2014·The European Journal of Neuroscience·Kimberley A PitmanStephanie L Borgland
Jun 7, 2012·Neuroscience and Biobehavioral Reviews·Lampros Perogamvros, Sophie Schwartz
Jun 19, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A P VaraniG N Balerio
Feb 23, 2013·Journal of Medicinal Chemistry·Changho HanDavid A Colby

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.