GABAergic and glutamatergic modulation of spontaneous and motor-cortex-evoked complex spike activity

Journal of Neurophysiology
E J Lang

Abstract

Olivocerebellar activity is organized such that synchronous complex spikes occur primarily among Purkinje cells located within the same parasagittally oriented strip of cortex. Previous findings have shown that this synchrony distribution is modulated by the release of GABA and glutamate within the inferior olive, which probably act by controlling the efficacy of the electrotonic coupling between olivary neurons. The relative strengths of these two neurotransmitters in modulating the patterns of synchrony were compared by obtaining multiple electrode recordings of spontaneous crus 2a complex spike activity during intraolivary injection of solutions containing a GABA(A) (picrotoxin) and/or AMPA [1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium (NBQX)] receptor antagonist. Injection of either antagonist led to increased synchrony between cells located within the same parasagittally oriented approximately 250-microm-wide cortical strip. Picrotoxin also increased complex spike synchrony among cells located in different cortical strips, leading to a less prominent banding pattern, whereas injections of NBQX tended to decrease complex spike synchrony among such cells, enhancing the banding pattern. The ...Continue Reading

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Citations

Sep 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·S KhosrovaniM T G De Jeu
Oct 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·Norio WadaShigetada Nakanishi
Feb 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gilad A JacobsonDana Cohen
Aug 28, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ilker OzdenSamuel S-H Wang
Nov 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah P Marshall, Eric J Lang
Mar 5, 2011·The Cerebellum·Eric J Lang, Timothy A Blenkinsop
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Apr 14, 2011·The Journal of Physiology·Rodolfo R Llinás
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Dec 17, 2005·The Journal of Physiology·Eric J LangRodolfo Llinás
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Jun 19, 2021·Stem Cells and Development·Jennifer PardieckShelly Sakiyama-Elbert

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