GABAergic and glutaminergic modulation of centrally evoked arrhythmias in rats

Hypertension
A CrambesP Bousquet

Abstract

A standard electrical stimulus applied to the posterior hypothalamus evoked cardiac arrhythmogenic responses in the spontaneously hypertensive rat. Isolated premature ventricular beats or doublets and nonsustained ventricular tachycardic salvos were observed. This effect was associated with a large rise in blood pressure (79 +/- 3 mm Hg). The same stimulus in normotensive Wistar-Kyoto rats produced no significant cardiac arrhythmias, and the rise in blood pressure was smaller (36 +/- 2 mm Hg). We investigated the influence of baclofen, a GABAB receptor agonist, and two N-methyl-D-aspartate receptor antagonists on the arrhythmogenic response to hypothalamic stimulation. Intravenous baclofen (3 mg/kg) had no effect in the normotensive Wistar-Kyoto rats, but in the spontaneously hypertensive rats it enhanced the adjusted mean value of the number of extrasystoles from 0.5 +/- 0.5 to 18 +/- 1 (P < .001). This value was also increased (from 3 +/- 1 to 17 +/- 1, P < .001) by an intracisternal injection of baclofen (1 micrograms/kg). This facilitatory effect of baclofen was prevented by treatment with atenolol (0.5 mg/kg). Two glutamate receptor antagonists, ketamine (7.5 mg/kg IV) and kynurenic acid (200 micrograms/kg intracerebrovent...Continue Reading

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Citations

Mar 22, 2002·European Journal of Pharmacology·Kazuhito HayakawaKatsuo Kamata
Jul 23, 1998·Clinical and Experimental Pharmacology & Physiology·P BousquetJ Feldman
Dec 7, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Bożena BądzyńskaElżbieta Kompanowska-Jezierska

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