GABAergic and glycinergic inhibition sharpens tuning for frequency modulations in the inferior colliculus of the big brown bat

Journal of Neurophysiology
U Koch, B Grothe

Abstract

Discrimination of amplitude and frequency modulated sounds is an important task of auditory processing. Experiments have shown that tuning of neurons to sinusoidally frequency- and amplitude-modulated (SFM and SAM, respectively) sounds becomes successively narrower going from lower to higher auditory brain stem nuclei. In the inferior colliculus (IC), many neurons are sharply tuned to the modulation frequency of SFM sounds. The purpose of this study was to determine whether GABAergic or glycinergic inhibition is involved in shaping the tuning for the modulation frequency of SFM sounds in IC neurons of the big brown bat (Eptesicus fuscus). We recorded the response of 56 single units in the central nucleus of the IC to SFM stimuli before and during the application of the gamma-aminobutyric acid-A (GABAA) receptor antagonist bicuculline or the glycine receptor antagonist strychnine. To evaluate tuning to the modulation frequency, the normalized spike count (normalized according to the maximal response for each condition tested) was plotted versus the modulation frequency and the upper and lower 50% cutoff points were determined. Bicuculline increased the upper cutoff in 46% of the neurons by >/=25%. The lower cutoff decreased in 4...Continue Reading

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Citations

Jun 2, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Chung Hsin Wu, Philip H-S Jen
Jul 22, 2011·Journal of Neurophysiology·Anthony J Williams, Zoltan M Fuzessery
Mar 22, 2013·Journal of Neurophysiology·Richard A FelixAnna K Magnusson
Jun 30, 2014·Brain Structure & Function·Richard A FelixAlbert S Berrebi
Apr 12, 2000·Journal of Neurophysiology·U Koch, B Grothe
Apr 6, 2012·PloS One·David Pérez-GonzálezManuel S Malmierca
Jun 1, 2015·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Jia TangQi-Cai Chen
Feb 2, 2015·Cellular and Molecular Life Sciences : CMLS·Cal F RabangGuangying K Wu
May 23, 2003·The Journal of Comparative Neurology·Melissa H RosenbergerEllen Covey
May 30, 2012·Journal of Cognitive Neuroscience·I-Hui HsiehKourosh Saberi
Oct 25, 2013·Journal of Neurophysiology·Rui CaiDonald M Caspary
Mar 4, 2003·Journal of Neurophysiology·Randy J KuleszaAlbert S Berrebi
Jan 31, 2008·Histochemistry and Cell Biology·Julia DlugaiczykMarlies Knipper
Nov 14, 2019·Journal of Neurophysiology·Boris GourévitchChristine V Portfors
Apr 2, 2004·Journal of Neurophysiology·Thomas J ParkBenedikt Grothe
May 7, 2015·Neuroscience·R Cai, D M Caspary

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