GABAergic and glycinergic inhibitory mechanisms in the lamprey respiratory control

Brain Research
Fulvia BongianniTito Pantaleo

Abstract

The specific role of gamma-aminobutyric acid (GABA) and glycine receptors in respiratory rhythm generation and pattern formation was investigated in in vitro brainstem preparations from adult lampreys by analyzing the changes in respiratory activity induced by bath application of specific antagonists, agonists, and uptake blockers. GABAA receptor blockade by bicuculline or picrotoxin increased both the frequency and amplitude of respiratory bursts. Similar effects were observed after glycine receptor blockade by strychnine. Combined bath application of bicuculline and strychnine markedly increased the frequency and amplitude of respiratory activity. These responses were associated, especially at the higher concentrations of the two drugs, with the appearance of tonic activity and irregular, high-frequency bursts followed by transient depression of respiratory activity. GABAA and glycine receptor agonists suppressed respiratory activity. These effects were prevented by bath application of the corresponding specific antagonists. GABAB receptor blockade by 2-hydroxysaclofen reduced the respiratory frequency but increased the peak amplitude of respiratory bursts. Activation of GABAB receptors suppressed respiratory activity. These ...Continue Reading

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Citations

Jul 21, 2012·Bulletin of Experimental Biology and Medicine·O A Vedyasova, A M Kovalyov
Sep 16, 2014·Respiratory Physiology & Neurobiology·Fulvia BongianniTito Pantaleo
Feb 5, 2014·The Journal of Physiology·Elenia CinelliFulvia Bongianni
Apr 29, 2014·Physiological and Biochemical Zoology : PBZ·Éric CôtéRichard Kinkead
Jun 10, 2009·Respiratory Physiology & Neurobiology·Richard Kinkead
Oct 24, 2007·Neuroscience·D MutoloT Pantaleo
Sep 16, 2017·Stress : the International Journal on the Biology of Stress·Rasha A Al WakeelMichel Fahmy Saad
Jan 16, 2008·The Journal of Comparative Neurology·Verona Villar-CerviñoMaría Celina Rodicio
Dec 23, 2016·Frontiers in Neuroanatomy·Daniel Romaus-SanjurjoMaría Celina Rodicio
Jul 25, 2021·Respiratory Physiology & Neurobiology·M J OlivaresJ Eugenín
Jul 31, 2021·Respiratory Physiology & Neurobiology·Donatella MutoloElenia Cinelli

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