PMID: 9182846Jun 30, 1997Paper

GABAergic and other noncholinergic basal forebrain neurons, together with cholinergic neurons, project to the mesocortex and isocortex in the rat

The Journal of Comparative Neurology
I GrittiB E Jones

Abstract

The extrathalamic relay from the brainstem reticular formation to the cerebral cortex in the basal forebrain has been thought to be constituted predominantly, if not exclusively, by cholinergic neurons. In contrast, the septohippocampal projection has been shown to contain an important contingent of gamma-aminobutyric acid (GABA)ergic neurons. In the present study, we investigated whether GABAergic neurons also contribute to the projection from the basal forebrain to neocortical regions, including the mesocortex (limbic) and the isocortex in the rat. For this purpose, retrograde transport of cholera toxin (CT) was examined from the medial prefrontal cortex for the mesocortex and from the parietal cortex for the isocortex and was combined with dual-immunohistochemical staining for either choline acetyltransferase (ChAT) or glutamic acid decarboxylase (GAD) in adjacent series of sections. Retrogradely labelled GAD+ neurons were codistributed with retrogradely labelled ChAT+ neurons through the basal forebrain from both the prefrontal and the parietal cortex, suggesting parallel, widespread cortical projections. The GAD+ cortically projecting cells were similar in size to the ChAT+ cells, thereby indicating that they comprise a co...Continue Reading

Citations

Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dewey E McLinNorman M Weinberger
Sep 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Oum Kaltoum HassaniBarbara E Jones
Feb 24, 2012·Journal of Neurophysiology·J M HawrylukE Arrigoni
Jul 23, 1999·Annals of the New York Academy of Sciences·L ZaborszkyI Kallo
Oct 5, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bruno BitonBernard Scatton
Jul 9, 2002·The European Journal of Neuroscience·Martin Sarter, John P Bruno
Feb 3, 2016·Brain Structure & Function·S MongiaE Mengual
Aug 13, 2003·The European Journal of Neuroscience·Ian D MannsBarbara E Jones
Sep 15, 2015·Nature Neuroscience·Jeffrey D MayseShih-Chieh Lin
Feb 27, 2003·The European Journal of Neuroscience·Anna V KalinchukTarja Porkka-Heiskanen
Sep 4, 2014·Brain Structure & Function·Raúl Peñas-Cazorla, M Teresa Vilaró
Aug 9, 2016·Brain Structure & Function·Joanne C DamborskyJerrel L Yakel
Aug 25, 2007·Brain Structure & Function·Walter B Hoover, Robert P Vertes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.