Sep 1, 1997

GABAergic cell subtypes and their synaptic connections in rat frontal cortex

Cerebral Cortex
Y Kawaguchi, Y Kubota

Abstract

Physiological, morphological and immunohistochemical characteristics of non-pyramidal cells in frontal cortex of young rats were studied in vitro by whole-cell recording and biocytin injection. Several groups of GABAergic non-pyramidal cells were identified: (i) parvalbumin fast-spiking (FS) cells with low input resistances and spikes of short duration, including extended plexus (basket) cells and chandelier cells. These cells showed abrupt episodes of non-adapting repetitive discharges; (ii) late-spiking (LS) cells exhibiting slowly developing ramp depolarizations, including neurogliaform cells; (iii) the remaining groups contained both burst-spiking (BS) or regular-spiking (RS) non-pyramidal (NP) cells. BSNP cells exhibited bursting activity (two or more spikes on slow depolarizing humps) from hyperpolarized potentials. Both these physiological types corresponded to a range of morphologies: (i) somatostatin-containing Martinotti cells with ascending axonal arbors to layer I (some were also positive for calbindin D28k); (ii) VIP-containing double bouquet cells with descending axonal arbors as well as arcade cells (these included small cells immunoreactive for CCK or calretinin). Each subtype of cells made GABAergic synapses on...Continue Reading

  • References
  • Citations641

References

  • We're still populating references for this paper, please check back later.

Mentioned in this Paper

Basket Cell Erythrocyte
Calbindin 1
Immunohistochemistry
Entire Upper Dental Arch
CALB2 gene
Neurons
Respiratory Burst
Reis-Bucklers' Corneal Dystrophy
Injection Procedure
Immunocytochemistry

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.