GABAergic circuitry in the opossum retina: a GABA release induced by L-aspartate

Experimental Brain Research
K C CalazaP F Gardino

Abstract

Glutamate and gamma-amino butyric acid (GABA) are the major excitatory and inhibitory neurotransmitters, respectively, in the central nervous system (CNS), including the retina. Although in a number of studies the retinal source of GABA was identified, in several species, as horizontal, amacrine cells and cells in the ganglion cell layer, nothing was described for the opossum retina. Thus, the first goal of this study was to determine the pattern of GABAergic cell expression in the South America opossum retina by using an immunohistochemical approach for GABA and for its synthetic enzyme, glutamic acid decarboxylase (GAD). GABA and GAD immunoreactivity showed a similar cellular pattern by appearing in a few faint horizontal cells, topic and displaced amacrine cells. In an effort to extend the knowledge of the opossum retinal circuitry, the possible influence of glutamatergic inputs in GABAergic cells was also studied. Retinas were stimulated with different glutamatergic agonists and aspartate (Asp), and the GABA remaining in the tissue was detected by immunohistochemical procedures. The exposure of retinas to NMDA and kainate resulted the reduction of the number of GABA immunoreactive topic and displaced amacrine cells. The Asp...Continue Reading

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Citations

Oct 2, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mário Cesar do Nascimento BevilaquaKarin C Calaza
May 10, 2008·Journal of Neurochemistry·Chiara BalliniMaria Grazia Giovannini
Mar 18, 2010·The Journal of Comparative Neurology·Chenying GuoNicholas C Brecha
Aug 8, 2013·Experimental Eye Research·Vivian Sayuri Miya-CoreixasKarin Calaza
Sep 8, 2006·Neurochemistry International·K C CalazaF G de Mello
Nov 23, 2017·Journal of Neurochemistry·Ivan DomithRoberto Paes-de-Carvalho

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