GABAergic control of the activity of the central nucleus of the amygdala in low- and high-anxiety rats

Neuropharmacology
A SkórzewskaA Płaźnik

Abstract

The aim of this study was to examine the role of GABAergic neurotransmission in amygdala nuclei in low- (LR) and high-anxiety (HR) rats after repeated corticosterone administration and acute injection of the benzodiazepine midazolam. The animals were divided into LR and HR groups based on the duration of their conditioned freezing in a contextual fear test (CFT). Repeated daily administration of corticosterone (20 mg/kg s.c.) for 21 injections increased anxiety-like behavior in the open field and reduced body weight in both the LR and HR groups. These effects of corticosterone administration were more pronounced in the HR group. Moreover, in the HR group, chronic corticosterone administration increased the duration of freezing in the CFT test compared with the appropriate control group and treated LR rats. The behavioral effects in HR rats were accompanied by an increase in the expression of c-Fos in the lateral (LA) and central (CeA) nuclei of the amygdala and by a decrease in GABA-A alpha-2 subunit density in the CeA. Acute midazolam administration significantly attenuated the neophobia and conditioned fear responses, decreased c-Fos expression in the LA and CeA, and increased alpha-2 subunit density in the CeA only in the HR...Continue Reading

References

Dec 1, 1987·Brain Research Bulletin·R R Terreberry, E J Neafsey
Dec 1, 1995·Brain Research. Molecular Brain Research·M OrchinikB S McEwen
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Jan 16, 2003·Physiology & Behavior·Anthony A Grace, J Amiel Rosenkranz
Dec 4, 2003·Behavioural Brain Research·Maria A MorganJoseph E LeDoux
Apr 15, 2004·Neurobiology of Learning and Memory·Cheryl D ConradRita A Fuchs
Jun 24, 2004·Journal of Neurophysiology·Denis ParéJoseph E Ledoux
Jun 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Rupshi MitraSumantra Chattarji
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pablo A Rodríguez ManzanaresVíctor A Molina
Sep 26, 2006·Journal of Neuroscience Research·Alexandra Kavushansky, Gal Richter-Levin
Dec 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ann E WilenskyJoseph E LeDoux
Dec 11, 2007·Behavioural Brain Research·Małgorzata LehnerAdam Płaźnik
May 27, 2009·Nature Reviews. Neuroscience·Benno RoozendaalSumantra Chattarji
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Joshua P JohansenJoseph E LeDoux
Apr 21, 2012·Brain Research·Elizabeth Palomares-CastilloMiguel Pérez de la Mora
Oct 24, 2012·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Mouna Maroun
Jul 13, 2013·Psychoneuroendocrinology·Vanessa A van AstHeather C Abercrombie
Aug 6, 2013·Frontiers in Neural Circuits·Seungho LeeJoung-Hun Kim
Jun 9, 2014·Neuron·Sevil Duvarci, Denis Pare

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Citations

Aug 30, 2018·Frontiers in Neuroscience·Fan JieBingjin Li
Jun 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Marie BarbierPierre-Yves Risold
Sep 18, 2021·Reviews in the Neurosciences·Bob JacobsLori Marino

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