PMID: 9541144Apr 16, 1998Paper

GABAergic function in detoxified heroin addicts: relationship to anxiety disorders

Psychiatry Research
G GerraF Brambilla

Abstract

The function of the GABAergic system was examined in 20 subjects with heroin dependence and abuse, 2 months after detoxification, and in 10 healthy volunteers, by measuring the growth hormone (GH) response to a challenge with the GABA B receptor agonist baclofen. Ten heroin addicts had comorbid anxiety disorder (Group A), while the other ten had heroin addiction uncomplicated by Axis I and II psychopathologies (Group B). GH responses to baclofen stimulation of Group A patients were significantly blunted, while those of Group B subjects did not differ from responses of healthy volunteers. Our data show that the function of the GABAergic system is impaired only in heroin addicts with comorbid anxiety disorders (anxious cluster), suggesting that the GABA system is not persistently influenced by prolonged exposure to opioid receptor stimulation.

References

Jan 1, 1978·European Journal of Pharmacology·R DingledineE Breuker
Mar 1, 1992·The Journal of Nervous and Mental Disease·S S LutharB J Rounsaville
Jul 1, 1991·Journal of the American Academy of Child and Adolescent Psychiatry·R MilinC Morse
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Mar 12, 1981·European Journal of Pharmacology·J Sawynok, F S Labella
Oct 1, 1983·Journal of Endocrinological Investigation·P ChioderaE Roti
Sep 1, 1982·The Journal of Nervous and Mental Disease·S L EyreH D Kleber
Jan 1, 1994·Journal of Psychosomatic Research·M Lader
Jan 1, 1993·Psychopharmacology·R BalonR Pohl
Dec 20, 1993·Behavioural Brain Research·F G GraeffR M Oliveira
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON

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Citations

Nov 21, 2000·Psychiatry Research·G GerraF Brambilla
Mar 4, 2000·Peptides·A L VaccarinoA J Kastin
Jan 9, 2001·Journal of Substance Abuse·G GerraF Brambilla
Mar 3, 2017·Journal of Addictions Nursing·Yatan Pal Singh BalharaRishab Gupta
Aug 14, 2020·International Clinical Psychopharmacology·Sung Young HuhTae Kyung Hong

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