GABAergic influences on ORX receptor-dependent abnormal motor behaviors and neurodegenerative events in fish

Toxicology and Applied Pharmacology
Rosa Maria FaccioloMarcello Canonaco

Abstract

At date the major neuroreceptors i.e. gamma-aminobutyric acid(A) (GABA(A)R) and orexin (ORXR) systems are beginning to be linked to homeostasis, neuroendocrine and emotional states. In this study, intraperitoneal treatment of the marine teleost Thalassoma pavo with the highly selective GABA(A)R agonist (muscimol, MUS; 0.1 microg/g body weight) and/or its antagonist bicuculline (BIC; 1 microg/g body weight) have corroborated a GABA(A)ergic role on motor behaviors. In particular, MUS induced moderate (p<0.05) and great (p<0.01) increases of swimming towards food sources and resting states after 24 (1 dose) and 96 (4 doses) h treatment sessions, respectively, when compared to controls. Conversely, BIC caused a very strong (p<0.001) reduction of the former behavior and in some cases convulsive swimming. From the correlation of BIC-dependent behavioral changes to neuronal morphological and ORXR transcriptional variations, it appeared that the disinhibitory action of GABA(A)R was very likely responsible for very strong and strong ORXR mRNA reductions in cerebellum valvula and torus longitudinalis, respectively. Moreover these effects were linked to evident ultra-structural changes such as shrunken cell membranes and loss of cytoplasm...Continue Reading

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Citations

Jul 21, 2012·Behavioural Brain Research·Rosa Maria FaccioloMarcello Canonaco
Nov 16, 2010·Behavioural Brain Research·Ennio AvolioMarcello Canonaco
Oct 15, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Merylin ZizzaRosa Maria Facciolo
Jan 31, 2020·Biology Open·Jacqueline WeidnerChristian Jørgensen
Dec 2, 2017·The Journal of Experimental Biology·Sergey Snigirov, Sergiy Sylantyev

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