GABAergic neuron death in the striatum following kainate-induced damage of hippocampal neurons: evidence for the role of NO in locomotion

The International Journal of Neuroscience
Yang-Hsin ShihYu-Show Fu

Abstract

The authors examined the role of nitric oxide (NO) in the relationship between kainate-induced neuronal death and locomotion changes. Locomotion was significantly increased 1 h after kainate injection, suggesting that kainate induced NO and dopamine release. Cell death occurred in the CA1 (41%) and CA3 (54%) regions at 12 h. At 7 days, GABAergic neurons in striatum were lost, suggesting possible pyramidal neuron synapse with striatal GABAergic neurons, and pyramidal neuron damage leading to deafferentation and degeneration of striatal GABAergic neurons. Pre-administration of Nw-nitro-L-arginine-methyl-ester or 7-nitroindazole reduced these effects. These results indicate that NO may modulate kainate-induced neuronal death and locomotion.

References

Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 14, 1980·Life Sciences·J V NadlerC W Cotman
Jan 1, 1994·Progress in Neurobiology·S R Vincent
Mar 28, 1994·Neuroscience Letters·E PrzegalińskiJ Siwanowicz
Nov 21, 1994·Neuroreport·A MülschS P Olesen
Jun 1, 1993·Journal of Neuroscience Research·G LonartK M Johnson
May 21, 1993·Brain Research. Developmental Brain Research·G L HolmesJ L Thompson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.