GABAergic signaling increases through the postnatal development to provide the potent inhibitory capability for the maturing demands of the prefrontal cortex.

Cellular and Molecular Neurobiology
Jihong CuiHui Xiang

Abstract

The developmental profile of the firing patterns and construction of synapse connection were studied in LTS interneurons of prefrontal cortex (PFC) in rats with age (from P7 to P30). We used whole cell patch-clamp recordings to characterize electrophysiological properties of LTS interneurons in PFC at different age stages, including the action potentials (APs), short-term plasticity (STP), evoked excitatory postsynaptic currents (eEPSCs), spontaneous excitatory postsynaptic currents (sEPSC), and spontaneous inhibitory postsynaptic current (sIPSC). The developmental profile of LTS interneurons in our research showed two phases changes. The early phase from P7-P11 to P16-P19 during which the development of individual LTS interneuron dominated and just some simple synaptic connections formed, the synaptic inputs from pyramidal cells play a promoting role for the maturation of LTS interneurons to some extent. This was based on the changes of APs, eEPSCs, and STP such as the curtailment of time course of APs, the increasing facilitation of STP before P16-P19 group. The late phase from P20-P23 to P > 27 during which the function of inhibitory cortex network enhanced and the characters of this inhibitory cortex network continually cha...Continue Reading

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Citations

Sep 29, 2011·Journal of Psychopharmacology·Jihong CuiHui Xiang

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