Gabapentin, an Analgesic Used Against Cancer-Associated Neuropathic Pain: Effects on Prostate Cancer Progression in an In Vivo Rat Model

Basic & Clinical Pharmacology & Toxicology
Ilknur BuganM B A Djamgoz

Abstract

A major problem associated with clinical management of cancer is controlling the accompanying pain, and various analgesics are in common use for this purpose. Recent evidence suggests that some of the targets of analgesics, such as ion channels and receptors, may also be involved in the cancer process, thereby raising the possibility that such use of some analgesics may impact upon cancer itself. The main aim of this study was to determine whether gabapentin, a common adjuvant analgesic in current use against cancer-associated neuropathic pain, would affect tumour development and progression in vivo. The Dunning rat model of prostate cancer was used. Strongly metastatic Mat-LyLu cells were implanted subcutaneously into syngeneic Copenhagen rats which were then treated every other day with 4.6-16.8 μg/kg gabapentin by gavage. Primary tumourigenesis was monitored daily. Lung metastases were counted and measured after killing the rats 21 days later. Gabapentin had no effect on primary tumourigenesis but produced dose-dependent effects on lung metastasis. Whilst 4.6 μg/kg had no effect, 9.1 μg/kg gabapentin decreased the number of lung metastases significantly by 64%. In contrast, 16.8 μg/kg gabapentin promoted metastasis significa...Continue Reading

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Citations

Sep 25, 2019·Medicina·Ayappa V SubramaniamChern Ein Oon
Apr 19, 2020·Basic & Clinical Pharmacology & Toxicology·Nahit RizanerSeyhan Altun
Aug 20, 2020·Human & Experimental Toxicology·B B BayrakR Yanardag
Apr 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong-Seok LeeHea-Young Cho
May 28, 2021·Toxicology Mechanisms and Methods·Pınar Koroglu-AydınRefiye Yanardag
Oct 13, 2021·Pain Management·Maria F RamirezJuan P Cata
Dec 1, 2021·Cell Biochemistry and Function·Pınar Koroglu AydınRefiye Yanardag

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