Gabapentin as an adjunct to paracervical block for perioperative pain management for first-trimester uterine aspiration: a randomized controlled trial

American Journal of Obstetrics and Gynecology
Tiffany P HailstorksLisa B Haddad

Abstract

Pain management approaches during uterine aspiration vary, which include local anesthetic, oral analgesics, moderate sedation, deep sedation, or a combination of approaches. For local anesthetic approaches specifically, we continue to have suboptimal pain control. Gabapentin as an adjunct to pain management has proven to be beneficial in gynecologic surgery. We sought to evaluate the impact of gabapentin on perioperative pain during surgical management of first-trimester abortion or early pregnancy loss with uterine aspiration under local anesthesia. We hypothesized that adding gabapentin to local anesthesia will reduce perioperative and postoperative pain associated with uterine aspiration. Secondary outcomes included tolerability of gabapentin and postoperative pain, nausea, vomiting, and anxiety. We conducted a randomized double-blinded placebo-controlled trial of gabapentin 600 mg given 1 to 2 hours preoperatively among subjects receiving a first-trimester uterine aspiration under paracervical block in an outpatient ambulatory surgery center. There were 111 subjects randomized. The primary outcome was pain at time of uterine aspiration as measured on a 100-mm visual analog scale. Secondary outcomes included pain at other pe...Continue Reading

References

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Aug 2, 2008·Contraception·Rameet H SinghPaul D Blumenthal
Jan 22, 2009·Obstetrics and Gynecology·Rebecca H AllenAlisa B Goldberg
May 2, 2009·Clinical Obstetrics and Gynecology·Karen R Meckstroth, Kavita Mishra
Nov 18, 2010·Anesthesia and Analgesia·Albert MooreJose C A Carvalho
May 9, 2014·Obstetrics and Gynecology·Nada AlayedTogas Tulandi
Aug 19, 2015·Contraception·Susan L Higginbotham
Aug 14, 2019·Obstetrics and Gynecology·Beverly A GrayLisa B Haddad

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