Gabapentin enacarbil (XP13512/GSK1838262) as an alternative treatment to dopaminergic agents for restless legs syndrome

Expert Opinion on Pharmacotherapy
Susan Imamura, Clete Kushida

Abstract

Gabapentin enacarbil (XP13512/GSK1838262) is being explored as an alternative treatment for restless legs syndrome (RLS), which currently relies heavily on dopaminergic agents; however, these latter medications have the reported complications of augmentation. Gabapentin enacarbil shows promising data that it may be equally to more efficacious and have an improved side effect profile than treatment with dopaminergic agents. Gabapentin enacarbil, examined in studies from 2004 to 2009, is a precursor to gabapentin and overcomes gabapentin's unfavorable pharmacokinetic profile and dose-dependent bioavailability. Randomized, controlled studies published in 2009 showed that gabapentin enacarbil outperformed placebo in improving quality and duration of sleep based on subjective report, investigator observation and objective measures in clinical trials. These trials show gabapentin enacarbil is well tolerated and safe, with a side-effect profile similar to gabapentin. The reader will gain a thorough understanding of the current treatments available for RLS and how gabapentin enacarbil offers a potential breakthrough in expanding on these treatment options for both improved efficacy and tolerability. Based on these findings, gabapentin ...Continue Reading

References

Aug 1, 1986·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·D BoghenJ Montplaisir
Jun 1, 1984·Acta Neurologica Scandinavica·P MontagnaE Lugaresi
Apr 30, 1999·The Journal of Clinical Psychiatry·H Lauerma, J Markkula
Feb 24, 2001·Psychiatry and Clinical Neurosciences·T KageyamaT Takemoto
Mar 13, 2001·European Neurology·C L BassettiC W Hess
Jun 8, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·E K TanK K Koh
Nov 13, 2001·American Journal of Human Genetics·A DesautelsG A Rouleau
Jul 20, 2002·Journal of Psychosomatic Research·Maurice M Ohayon, Thomas Roth
May 24, 2003·Brain : a Journal of Neurology·Maria Teresa BonatiGiorgio Casari
Jan 17, 2004·Sleep Medicine·John W Winkelman, Lindsay Johnston
Sep 15, 2004·Archives of Neurology·William OndoDejian Lai
Jun 16, 2005·Archives of Internal Medicine·Richard P AllenLuigi Ferini-Strambi
Jul 13, 2005·Archives of Neurology·M Leann DoddJ Eric Ahlskog
Mar 1, 2006·Expert Opinion on Pharmacotherapy·Clete A Kushida
Jul 11, 2006·American Journal of Human Genetics·Gary K ChenKenneth Lange
Jan 20, 2007·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G MerlinoG L Gigli
Feb 3, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Claudia TrenkwalderUNKNOWN CALDIR Study Group
Jul 20, 2007·The New England Journal of Medicine·Hreinn StefanssonKari Stefansson
Oct 2, 2008·Journal of Clinical Pharmacology·Kenneth C CundyDaniel M Canafax
Oct 18, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Claudia TrenkwalderCristina Sampaio
Jun 3, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Ludger GroteJan Ulfberg
Aug 12, 2009·Clinical Neuropharmacology·Arthur S WaltersUNKNOWN XP045 Study Group

❮ Previous
Next ❯

Citations

Jan 1, 2010·Journal of Central Nervous System Disease·Ruth JonesAndrea Eugenio Cavanna

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.