Abstract
Gabapentin is a new antiepileptic drug with an unknown mechanism of action and very favorable pharmacokinetic and safety profiles. An increasing number of reports have described the successful use of gabapentin in bipolar disorder in adults. A 13-year-old boy with bipolar I disorder, manic episode, and ADHD, was treated with gabapentin 1,500 mg/day as add-on therapy to carbamazepine and showed a marked response within 1 month. He had previously failed a divalproex trial, could not tolerate lithium, and carbamazepine could not control his symptoms and induced a low WBC. He remained euthymic 7 months after gabapentin was added. His Young Mania Rating Scale (YMRS) score was 27 when gabapentin was added, 9 after 1 month, 15 after 4 months, and 6 after 7 months. Controlled studies are needed to evaluate the possible anti-manic, mood stabilizing, and/or anti-depressant properties of gabapentin in youth.
Citations
Nov 10, 2006·Psychopharmacology·Sylvester Smarty, Robert L Findling
Dec 21, 2000·Current Psychiatry Reports·G A Carlson, S E Meyer
Jun 5, 2003·Journal of Affective Disorders·Mauro Giovanni CartaBernardo Carpiniello
Jun 7, 2002·Journal of the American Academy of Child and Adolescent Psychiatry·Kathleen Myers, Nancy C Winters
May 20, 1999·Pharmacotherapy·L Letterman, J S Markowitz
Aug 30, 2008·Neuropsychiatric Disease and Treatment·Naghmeh MokhberAllan H Young
Apr 8, 2003·CNS Spectrums·Robert A Kowatch, Melissa P DelBello
Nov 7, 1999·The Psychiatric Clinics of North America·L SanchezR Weller
Apr 6, 2004·The Psychiatric Clinics of North America·Elizabeth B WellerRonald A Weller
Oct 14, 2005·Paediatric Drugs·Arman Danielyan, Robert A Kowatch
Dec 5, 2008·Journal of Psychiatric Practice·Timothy S CareyCathy L Melvin
Dec 13, 2006·Harvard Review of Psychiatry·Melissa Lopez-Larson, Jean A Frazier
May 5, 2001·Expert Opinion on Pharmacotherapy·K D Chang, T A Ketter
Jun 7, 2005·Expert Opinion on Pharmacotherapy·Gabriele Masi
Aug 26, 2009·CNS Drugs·Thomas J Spencer
Jul 5, 2002·CNS Drugs·Kathryn J Macdonald, L Trevor Young
Aug 10, 1999·Current Opinion in Pediatrics·A S Robb
Mar 12, 2002·The Journal of School Nursing : the Official Publication of the National Association of School Nurses·J A NoviaskyY H Lee
Nov 28, 2017·Pediatric Clinics of North America·Ekaterina Stepanova, Robert L Findling